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    TGFBR3 transforming growth factor beta receptor 3 [ Gallus gallus (chicken) ]

    Gene ID: 374251, updated on 3-Dec-2024

    Summary

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    Symbol
    TGFBR3provided by CGNC
    Full Name
    transforming growth factor beta receptor 3provided by CGNC
    Primary source
    CGNC:4525
    See related
    Ensembl:ENSGALG00010022082
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See TGFBR3 in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (14078489..14188389)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (14085041..14195063)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene bromodomain testis-specific protein-like Neighboring gene bromodomain testis associated Neighboring gene uncharacterized LOC121111434 Neighboring gene translation initiation factor IF-2-like Neighboring gene cell division cycle 7 Neighboring gene HFM1, ATP dependent DNA helicase homolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Messenger RNA and protein expression analysis of betaglycan in the pituitary and ovary of the domestic hen. Sweeney SA, et al. Biol Reprod, 2005 Jan. PMID 15385424
    2. Regulation of H(2)S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process. Qianru C, et al. J Hazard Mater, 2021 Mar 15. PMID 33307448
    3. Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC. Townsend TA, et al. Cell Signal, 2012 Jan. PMID 21945156, Free PMC Article
    4. Expression of the type III TGFbeta receptor during chick organogenesis. Olivey HE, et al. Anat Rec A Discov Mol Cell Evol Biol, 2003 May. PMID 12704694
    5. Multiple transforming growth factor-beta isoforms and receptors function during epithelial-mesenchymal cell transformation in the embryonic heart. Mercado-Pimentel ME, et al. Cells Tissues Organs, 2007. PMID 17587820

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Regulation of H2S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process.
      Title: Regulation of H(2)S-induced necroptosis and inflammation in broiler bursa of Fabricius by the miR-15b-5p/TGFBR3 axis and the involvement of oxidative stress in this process.
    2. TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures
      Title: Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken.
    3. the cytoplasmic domain of TGFbeta receptor 3, specifically the 3 C-terminal amino acids required to bind GIPC, were required for TGFbeta-2 and bone morphogenetic protein-2 stimulated epithelial-mesenchymal transformation
      Title: Endocardial cell epithelial-mesenchymal transformation requires Type III TGFβ receptor interaction with GIPC.
    4. Data show that TGF-beta1, -beta2, and -beta3 and their receptors have distinct spatiotemporal developmental protein localization patterns in the developing tendon and suggest that these isoforms have independent roles in tendon development.
      Title: Spatiotemporal protein distribution of TGF-betas, their receptors, and extracellular matrix molecules during embryonic tendon development.
    5. expression of betaglycan mRNA in the anterior pituitary, consistent with known inhibin effects. Ovarian localization of betaglycan, particularly in the theca layer, suggests a paracrine role for inhibin
      Title: Messenger RNA and protein expression analysis of betaglycan in the pituitary and ovary of the domestic hen.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    transforming growth factor beta receptor type 3
    Names
    transforming growth factor, beta receptor III (betaglycan, 300kDa)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204339.2 → NP_989670.1  transforming growth factor beta receptor type 3 precursor

      See identical proteins and their annotated locations for NP_989670.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000239
      UniProtKB/TrEMBL
      A0A8V0ZNT3, Q90998
      Related
      ENSGALP00010032349.1, ENSGALT00010053708.1
      Conserved Domains (1) summary
      smart00241
      Location:446 → 718
      ZP; Zona pellucida (ZP) domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      14078489..14188389
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040704478.2 → XP_040560412.1  transforming growth factor beta receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZNT3, Q90998
      Conserved Domains (1) summary
      smart00241
      Location:446 → 718
      ZP; Zona pellucida (ZP) domain

    2. XM_040704479.2 → XP_040560413.1  transforming growth factor beta receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZNT3, Q90998
      Conserved Domains (1) summary
      smart00241
      Location:446 → 718
      ZP; Zona pellucida (ZP) domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      14085041..14195063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046922229.1 → XP_046778185.1  transforming growth factor beta receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZNT3, Q90998

    2. XM_046922230.1 → XP_046778186.1  transforming growth factor beta receptor type 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZNT3, Q90998
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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