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    DKK4 dickkopf WNT signaling pathway inhibitor 4 [ Gallus gallus (chicken) ]

    Gene ID: 374156, updated on 17-Aug-2024

    Summary

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    Symbol
    DKK4provided by CGNC
    Full Name
    dickkopf WNT signaling pathway inhibitor 4provided by CGNC
    Primary source
    CGNC:2791
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    DKK1
    Orthologs
    human mouse all
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    Genomic context

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    See DKK4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (10957318..10958457)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (10828419..10829860)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene APOBEC1 complementation factor Neighboring gene protein kinase, cGMP-dependent, type I Neighboring gene uncharacterized LOC112532686 Neighboring gene uncharacterized LOC121111143 Neighboring gene uncharacterized LOC124418085

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of Wnt/β-catenin pathway by Dickkopf-1 [corrected] affects midfacial morphogenesis in chick embryo. Kawakami M, et al. J Biosci Bioeng, 2014 Jun. PMID 24378667
    2. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Mukhopadhyay M, et al. Dev Cell, 2001 Sep. PMID 11702953
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dkk-1 regulates maxillary morphogenesis in chick embryos through Lhx8, Msx1 and Msx2 signals.
      Title: Inhibition of Wnt/β-catenin pathway by Dickkopf-1 [corrected] affects midfacial morphogenesis in chick embryo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables co-receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables receptor antagonist activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dickkopf-related protein 1
    Names
    dickkopf WNT signaling pathway inhibitor 1
    dickkopf homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10957318..10958457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040702954.2 → XP_040558888.1  dickkopf-related protein 1 isoform X1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10828419..10829860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040674752.2 → XP_040530686.1  dickkopf-related protein 1 isoform X2

      Conserved Domains (1) summary
      pfam04706
      Location:63 → 115
      Dickkopf_N; Dickkopf N-terminal cysteine-rich region
    Nucleotide Protein
    Heading Accession and Version

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