DSCAM DS cell adhesion molecule [Gallus gallus (chicken)] - Gene

Summary

Symbol: DSCAMprovided by CGNC
Full Name: DS cell adhesion moleculeprovided by CGNC
Primary source: CGNC:12063
See related: Ensembl:ENSGALG00010013589
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (108317436..108781357, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (108407050..108870534, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DSCAM has roles in axonal decussation and fasciculation of chick spinal interneurons
Title: Roles of DSCAM in axonal decussation and fasciculation of chick spinal interneurons.
closely related adhesion molecules--Dscam, DscamL, Sidekick-1 and Sidekick-2--are expressed in chick by non-overlapping subsets of interneurons and RGCs that form synapses in distinct IPL sublaminae
Title: Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in dendrite self-avoidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: Down syndrome cell adhesion molecule homolog

Names: Down syndrome cell adhesion molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396519.1 → NP_001383448.1 Down syndrome cell adhesion molecule homolog precursor

Status: VALIDATED

Source sequence(s)

JAENSK010000020

UniProtKB/TrEMBL

A0A8V0YKS9, A0A8V0YN70

Related

ENSGALP00010019410.1, ENSGALT00010032764.1

Conserved Domains (8) summary

smart00410
Location:236 → 310

IG_like; Immunoglobulin like

cd00063
Location:1380 → 1470

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13927
Location:1287 → 1363

Ig_3; Immunoglobulin domain

cd00096
Location:406 → 409

Ig; Ig strand A [structural motif]

cd05734
Location:689 → 784

Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd05735
Location:785 → 884

Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)

cd20958
Location:504 → 593

IgI_5_Dscam; Fifth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains

cl11960
Location:406 → 501

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

108317436..108781357 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046940373.1 → XP_046796329.1 Down syndrome cell adhesion molecule homolog isoform X1

UniProtKB/Swiss-Prot

F1NY98

UniProtKB/TrEMBL

A0A8V0YF12

Related

ENSGALP00010019428.1, ENSGALT00010032801.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

108407050..108870534 complement

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GenBank, FASTA, Sequence Viewer (Graphics)