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    P4HA2 prolyl 4-hydroxylase subunit alpha 2 [ Gallus gallus (chicken) ]

    Gene ID: 416326, updated on 14-Dec-2024

    Summary

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    Symbol
    P4HA2provided by CGNC
    Full Name
    prolyl 4-hydroxylase subunit alpha 2provided by CGNC
    Primary source
    CGNC:50226
    See related
    Ensembl:ENSGALG00010016225
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See P4HA2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (16344620..16368673, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (16356221..16380367, complement)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene interleukin 3 Neighboring gene interleukin-like Neighboring gene uncharacterized LOC121106692 Neighboring gene PDZ and LIM domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables L-ascorbic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables procollagen-proline 4-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prolyl 4-hydroxylase subunit alpha-2
    Names
    4-PH alpha-2
    procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
    procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2
    prolyl 4-hydroxylase alpha-2 subunit
    prolyl 4-hydroxylase, alpha polypeptide II
    NP_001006155.1
    XP_015149508.2
    XP_015149509.2
    XP_015149512.2
    XP_025010627.2
    XP_025010628.2
    XP_025010629.2
    XP_040502858.1
    XP_040502859.1
    XP_040502860.1
    XP_040502861.1
    XP_046756336.1
    XP_046756337.1
    XP_046756339.1
    XP_046782968.1
    XP_046782969.1
    XP_046782970.1
    XP_046782971.1
    XP_046782972.1
    XP_046782973.1
    XP_046782974.1
    XP_046782975.1
    XP_046782976.1
    XP_046782977.1
    XP_046782978.1
    XP_046782979.1
    XP_046782980.1
    XP_046782981.1
    XP_046782982.1
    XP_046782983.1
    XP_046782985.1
    XP_046782986.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006155.1 → NP_001006155.1  prolyl 4-hydroxylase subunit alpha-2 precursor

      See identical proteins and their annotated locations for NP_001006155.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ719729
      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2
      Related
      ENSGALP00010022540.1, ENSGALT00010039027.1
      Conserved Domains (2) summary
      smart00702
      Location:347 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 113
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      16344620..16368673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046900381.1 → XP_046756337.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2

    2. XM_025154860.3 → XP_025010628.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (1) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    3. XM_040646926.2 → XP_040502860.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (2) summary
      smart00702
      Location:347 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 113
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    4. XM_046900380.1 → XP_046756336.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2

    5. XM_015294023.4 → XP_015149509.2  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2
      Related
      ENSGALP00010022545.1, ENSGALT00010039037.1
      Conserved Domains (1) summary
      smart00702
      Location:347 → 498
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    6. XM_015294022.4 → XP_015149508.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (1) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    7. XM_046900383.1 → XP_046756339.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2

    8. XM_040646924.2 → XP_040502858.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (1) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    9. XM_025154859.3 → XP_025010627.2  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2
      Related
      ENSGALP00010022530.1, ENSGALT00010039002.1
      Conserved Domains (1) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    10. XM_025154861.3 → XP_025010629.2  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (2) summary
      smart00702
      Location:347 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 113
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    11. XM_040646925.2 → XP_040502859.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2
      Conserved Domains (1) summary
      smart00702
      Location:347 → 520
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    12. XM_040646927.2 → XP_040502861.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2
      Related
      ENSGALP00010022534.1, ENSGALT00010039013.1
      Conserved Domains (2) summary
      smart00702
      Location:347 → 518
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
      pfam08336
      Location:27 → 113
      P4Ha_N; Prolyl 4-Hydroxylase alpha-subunit, N-terminal region

    13. XM_015294026.4 → XP_015149512.2  prolyl 4-hydroxylase subunit alpha-2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YWU9
      Related
      ENSGALP00010022523.1, ENSGALT00010038987.1
      Conserved Domains (1) summary
      smart00702
      Location:347 → 458
      P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      16356221..16380367 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046927026.1 → XP_046782982.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2

    2. XM_046927019.1 → XP_046782975.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2

    3. XM_046927022.1 → XP_046782978.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2

    4. XM_046927013.1 → XP_046782969.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    5. XM_046927016.1 → XP_046782972.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    6. XM_046927025.1 → XP_046782981.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2

    7. XM_046927018.1 → XP_046782974.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2

    8. XM_046927012.1 → XP_046782968.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    9. XM_046927027.1 → XP_046782983.1  prolyl 4-hydroxylase subunit alpha-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YV98, Q5W4S2

    10. XM_046927015.1 → XP_046782971.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    11. XM_046927020.1 → XP_046782976.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2

    12. XM_046927023.1 → XP_046782979.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2

    13. XM_046927014.1 → XP_046782970.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    14. XM_046927021.1 → XP_046782977.1  prolyl 4-hydroxylase subunit alpha-2 isoform X1

      UniProtKB/TrEMBL
      Q5W4S2

    15. XM_046927024.1 → XP_046782980.1  prolyl 4-hydroxylase subunit alpha-2 isoform X2

      UniProtKB/Swiss-Prot
      Q5ZLK5
      UniProtKB/TrEMBL
      Q5W4S2

    16. XM_046927017.1 → XP_046782973.1  prolyl 4-hydroxylase subunit alpha-2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YV94, Q5W4S2

    17. XM_046927029.1 → XP_046782985.1  prolyl 4-hydroxylase subunit alpha-2 isoform X6

      UniProtKB/TrEMBL
      A0A8V0YUU1

    18. XM_046927030.1 → XP_046782986.1  prolyl 4-hydroxylase subunit alpha-2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YWU9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZLK5.1 GenPept UniProtKB/Swiss-Prot:Q5ZLK5

    Gene LinkOut

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