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    PRKCB protein kinase C beta [ Gallus gallus (chicken) ]

    Gene ID: 416567, updated on 17-Aug-2024

    Summary

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    Symbol
    PRKCBprovided by CGNC
    Full Name
    protein kinase C betaprovided by CGNC
    Primary source
    CGNC:50286
    See related
    Ensembl:ENSGALG00010018355
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PRKCB1
    Orthologs
    human mouse all
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    Genomic context

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    See PRKCB in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (6666417..6744488)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (6662333..6740450)

    Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene leucine carboxyl methyltransferase 1 Neighboring gene aquaporin 8 Neighboring gene microRNA 1615 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 3 Neighboring gene uncharacterized LOC107054619

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake. Tunsophon S, et al. Steroids, 2010 Apr. PMID 20079367
    2. Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells. Numaga T, et al. J Cell Sci, 2010 Mar 15. PMID 20179100, Free PMC Article
    3. The phylogenetic relationship of tetrapod, coelacanth, and lungfish revealed by the sequences of forty-four nuclear genes. Takezaki N, et al. Mol Biol Evol, 2004 Aug. PMID 15128875
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PKCalpha and PKCbeta are both involved in steroid-stimulated phosphate uptake.
      Title: Protein kinase C isotypes in signal transduction for the 1,25D3-MARRS receptor (ERp57/PDIA3) in steroid hormone-stimulated phosphate uptake.
    2. TRPC3 functions as both a Ca(2+)-permeable channel and a protein scaffold at the plasma membrane for downstream PKCbeta activation in B cells.
      Title: Ca2+ influx and protein scaffolding via TRPC3 sustain PKCbeta and ERK activation in B cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein kinase C beta type
    Names
    protein kinase C, beta 1
    XP_015149966.1
    XP_015149967.1
    XP_040539945.1
    XP_040539946.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      6666417..6744488
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015294481.3 → XP_015149967.1  protein kinase C beta type isoform X2

      UniProtKB/TrEMBL
      A0A1D5PCZ1
      Related
      ENSGALP00010026368.1, ENSGALT00010044315.1
      Conserved Domains (4) summary
      cd04026
      Location:158 → 288
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd20833
      Location:34 → 91
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:101 → 154
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cl21453
      Location:340 → 663
      PKc_like; Protein Kinases, catalytic domain

    2. XM_015294480.4 → XP_015149966.1  protein kinase C beta type isoform X1

      UniProtKB/TrEMBL
      A0A1D5PUY5
      Related
      ENSGALP00010026366.1, ENSGALT00010044313.1
      Conserved Domains (4) summary
      cd04026
      Location:158 → 288
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05616
      Location:340 → 662
      STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
      cd20833
      Location:34 → 91
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:101 → 154
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      6662333..6740450
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040684012.2 → XP_040539946.1  protein kinase C beta type isoform X2

      UniProtKB/TrEMBL
      A0A1D5PCZ1
      Conserved Domains (4) summary
      cd04026
      Location:158 → 288
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd20833
      Location:34 → 91
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:101 → 154
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cl21453
      Location:340 → 663
      PKc_like; Protein Kinases, catalytic domain

    2. XM_040684011.2 → XP_040539945.1  protein kinase C beta type isoform X1

      UniProtKB/TrEMBL
      A0A1D5PUY5
      Conserved Domains (4) summary
      cd04026
      Location:158 → 288
      C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
      cd05616
      Location:340 → 662
      STKc_cPKC_beta; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta
      cd20833
      Location:34 → 91
      C1_cPKC_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
      cd20836
      Location:101 → 154
      C1_cPKC_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the classical (or conventional) protein kinase C (cPKC) family
    Nucleotide Protein
    Heading Accession and Version

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