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    PLCB2 phospholipase C beta 2 [ Gallus gallus (chicken) ]

    Gene ID: 423014, updated on 17-Aug-2024

    Summary

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    Symbol
    PLCB2provided by CGNC
    Full Name
    phospholipase C beta 2provided by CGNC
    Primary source
    CGNC:3557
    See related
    Ensembl:ENSGALG00010023305
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PLCB2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (843871..882864, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (838484..877478, complement)

    Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene BUB1 mitotic checkpoint serine/threonine kinase B Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene InaF motif containing 2 Neighboring gene C15orf52 homolog Neighboring gene uncharacterized LOC121113249

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
    XP_015141761.2
    XP_015141762.2
    XP_025007118.2
    XP_040528529.1
    XP_040528530.1
    XP_040528531.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      843871..882864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025151350.3 → XP_025007118.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZVU8, A0A8V1A068
      Related
      ENSGALP00010034550.1, ENSGALT00010056828.1
      Conserved Domains (5) summary
      cd00275
      Location:681 → 800
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 647
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:977 → 1144
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    2. XM_015286275.4 → XP_015141761.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZVU8
      Conserved Domains (5) summary
      cd00275
      Location:612 → 731
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:242 → 578
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:908 → 1075
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16209
      Location:80 → 230
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
      cl17171
      Location:6 → 75
      PH-like; Pleckstrin homology-like domain

    3. XM_015286276.4 → XP_015141762.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZVU8
      Conserved Domains (5) summary
      cd00275
      Location:509 → 628
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:139 → 475
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:805 → 972
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15898
      Location:10 → 39
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:1 → 127
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      838484..877478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040672595.2 → XP_040528529.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZVU8, A0A8V1A068
      Conserved Domains (5) summary
      cd00275
      Location:681 → 800
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:311 → 647
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:977 → 1144
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13361
      Location:17 → 144
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      cd16209
      Location:149 → 299
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)

    2. XM_040672596.2 → XP_040528530.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZVU8
      Conserved Domains (5) summary
      cd00275
      Location:612 → 731
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:242 → 578
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:908 → 1075
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd16209
      Location:80 → 230
      EFh_PI-PLCbeta2; EF-hand motif found in phosphoinositide phospholipase C beta 2 (PI-PLC-beta2)
      cl17171
      Location:6 → 75
      PH-like; Pleckstrin homology-like domain

    3. XM_040672597.2 → XP_040528531.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0ZVU8
      Conserved Domains (5) summary
      cd00275
      Location:509 → 628
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08624
      Location:139 → 475
      PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
      COG1196
      Location:805 → 972
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd15898
      Location:10 → 39
      EFh_PI-PLC; EF-hand motif [structural motif]
      cl28895
      Location:1 → 127
      EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    Nucleotide Protein
    Heading Accession and Version

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