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    DPYD dihydropyrimidine dehydrogenase [ Gallus gallus (chicken) ]

    Gene ID: 429083, updated on 17-Aug-2024

    Summary

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    Official Symbol
    DPYDprovided by CGNC
    Official Full Name
    dihydropyrimidine dehydrogenaseprovided by CGNC
    Primary source
    CGNC:4104
    See related
    Ensembl:ENSGALG00010024191
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See DPYD in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 8 NC_052539.1 (12309480..12626349)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 8 NC_052580.1 (12317324..12633486)

    Chromosome 8 - NC_052539.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101750449 Neighboring gene uncharacterized LOC121113423 Neighboring gene microRNA 137 Neighboring gene uncharacterized LOC101750667 Neighboring gene uncharacterized LOC124418142 Neighboring gene polypyrimidine tract binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells. Rengaraj D, et al. Theriogenology, 2013 Jan 1. PMID 23102846
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene DPYD was more highly expressed in the chicken primordial germ cells than that of stage X blastoderms.
      Title: Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables dihydropyrimidine dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron-sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables uracil binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thymine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in uracil catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dihydropyrimidine dehydrogenase; dihydropyrimidine dehydrogenase [NADP(+)]
    XP_025008718.1
    XP_025008719.1
    XP_040533703.1
    XP_040533704.1
    XP_040533705.1
    XP_040533706.1
    XP_040533707.1
    XP_040560906.1
    XP_040560907.1
    XP_426639.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      12309480..12626349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025152950.3 → XP_025008718.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

      UniProtKB/TrEMBL
      E1C4J1
      Conserved Domains (3) summary
      cd02940
      Location:456 → 758
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:883 → 941
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:2 → 437
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    2. XM_025152951.3 → XP_025008719.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZWJ2
      Conserved Domains (3) summary
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:959 → 1017
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    3. XM_426639.8 → XP_426639.3  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWJ2
      Related
      ENSGALP00010036012.1, ENSGALT00010059048.1
      Conserved Domains (3) summary
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:946 → 1004
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    4. XM_040704972.2 → XP_040560906.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZRA5
      Related
      ENSGALP00010035989.1, ENSGALT00010059025.1
      Conserved Domains (2) summary
      cd02940
      Location:532 → 814
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    5. XM_040704973.2 → XP_040560907.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X5

      Conserved Domains (1) summary
      cl40752
      Location:53 → 508
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    RNA

    1. XR_003076346.3 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      12317324..12633486
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040677771.2 → XP_040533705.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X3

      UniProtKB/TrEMBL
      E1C4J1
      Conserved Domains (3) summary
      cd02940
      Location:456 → 758
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:883 → 941
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:2 → 437
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    2. XM_040677769.2 → XP_040533703.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZWJ2
      Conserved Domains (3) summary
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:959 → 1017
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    3. XM_040677770.2 → XP_040533704.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZWJ2
      Conserved Domains (3) summary
      cd02940
      Location:532 → 834
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      pfam14697
      Location:946 → 1004
      Fer4_21; 4Fe-4S dicluster domain
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    4. XM_040677772.2 → XP_040533706.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X4

      UniProtKB/TrEMBL
      A0A8V0ZRA5
      Conserved Domains (2) summary
      cd02940
      Location:532 → 814
      DHPD_FMN; Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and ...
      cl40752
      Location:53 → 513
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    5. XM_040677773.2 → XP_040533707.1  dihydropyrimidine dehydrogenase [NADP(+)] isoform X5

      Conserved Domains (1) summary
      cl40752
      Location:53 → 508
      GltD; NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]

    RNA

    1. XR_005852171.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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