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    Fastkd5 FAST kinase domains 5 [ Mus musculus (house mouse) ]

    Gene ID: 380601, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fastkd5provided by MGI
    Official Full Name
    FAST kinase domains 5provided by MGI
    Primary source
    MGI:MGI:2139469
    See related
    Ensembl:ENSMUSG00000079043 AllianceGenome:MGI:2139469
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA1792
    Summary
    Predicted to enable rRNA binding activity. Predicted to be involved in mitochondrial RNA processing and regulation of mitochondrial mRNA stability. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and nose. Orthologous to human FASTKD5 (FAST kinase domains 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in liver E14 (RPKM 2.8), CNS E11.5 (RPKM 2.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fastkd5 in Genome Data Viewer
    Location:
    2 F1; 2 63.24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (130455766..130471922, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (130613846..130630002, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene oxytocin Neighboring gene arginine vasopressin Neighboring gene U box domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5982 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:130461487-130461688 Neighboring gene leucine zipper, putative tumor suppressor family member 3 Neighboring gene DDRGK domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10144

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration. Simarro M, et al. Biochem Biophys Res Commun, 2010 Oct 22. PMID 20869947, Free PMC Article
    2. Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Cheong A, et al. Development, 2020 May 26. PMID 32376682, Free PMC Article
    3. Quantitative Proteomic Analysis Reveals apoE4-Dependent Phosphorylation of the Actin-Regulating Protein VASP. Cakir Z, et al. Mol Cell Proteomics, 2023 May. PMID 37019383, Free PMC Article
    4. CHIP as a membrane-shuttling proteostasis sensor. Kopp Y, et al. Elife, 2017 Nov 1. PMID 29091030, Free PMC Article
    5. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13149, KIAA1792, MGC60835

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables rRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial RNA processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial RNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitochondrial mRNA stability IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial nucleoid ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial nucleoid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ribonucleoprotein granule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FAST kinase domain-containing protein 5, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001146084.2 → NP_001139556.2  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL731707
      Consensus CDS
      CCDS50713.2
      UniProtKB/Swiss-Prot
      Q3UNY5, Q5DTV0, Q7TMV3
      UniProtKB/TrEMBL
      A0A0R4J291
      Conserved Domains (3) summary
      smart00952
      Location:697 → 756
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:430 → 499
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:511 → 600
      FAST_2; FAST kinase-like protein, subdomain 2

    2. NM_001377124.1 → NP_001364053.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AL731707
      UniProtKB/Swiss-Prot
      Q3UNY5, Q5DTV0, Q7TMV3
      UniProtKB/TrEMBL
      A0A0R4J291
      Related
      ENSMUSP00000105891.3, ENSMUST00000110262.3
      Conserved Domains (3) summary
      smart00952
      Location:697 → 756
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:430 → 499
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:511 → 600
      FAST_2; FAST kinase-like protein, subdomain 2

    3. NM_001377125.1 → NP_001364054.1  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      AL731707
      UniProtKB/Swiss-Prot
      Q3UNY5, Q5DTV0, Q7TMV3
      UniProtKB/TrEMBL
      A0A0R4J291
      Related
      ENSMUSP00000137385.2, ENSMUST00000179273.2
      Conserved Domains (3) summary
      smart00952
      Location:697 → 756
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:430 → 499
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:511 → 600
      FAST_2; FAST kinase-like protein, subdomain 2

    4. NM_198176.3 → NP_937819.3  FAST kinase domain-containing protein 5, mitochondrial

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL731707
      Consensus CDS
      CCDS50713.2
      UniProtKB/Swiss-Prot
      Q3UNY5, Q5DTV0, Q7TMV3
      UniProtKB/TrEMBL
      A0A0R4J291
      Conserved Domains (3) summary
      smart00952
      Location:697 → 756
      RAP; This domain is found in various eukaryotic species, particularly in apicomplexans
      pfam06743
      Location:430 → 499
      FAST_1; FAST kinase-like protein, subdomain 1
      pfam08368
      Location:511 → 600
      FAST_2; FAST kinase-like protein, subdomain 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      130455766..130471922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TMV3.1 GenPept UniProtKB/Swiss-Prot:Q7TMV3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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