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    RELN reelin [ Gallus gallus (chicken) ]

    Gene ID: 427850, updated on 3-Dec-2024

    Summary

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    Symbol
    RELNprovided by CGNC
    Full Name
    reelinprovided by CGNC
    Primary source
    CGNC:6211
    See related
    Ensembl:ENSGALG00010009720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See RELN in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    65
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (13244082..13517140, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (13381349..13654420, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene solute carrier family 26 member 5 Neighboring gene uncharacterized LOC112533002 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene uncharacterized LOC124417187 Neighboring gene origin recognition complex subunit 5 Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC121109078

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle. Eresheim C, et al. J Biol Chem, 2014 Apr 4. PMID 24573679, Free PMC Article
    2. Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick. Yip YP, et al. J Comp Neurol, 2011 Jul 1. PMID 21452229
    3. Reelin mRNA expression during embryonic brain development in the chick. Bernier B, et al. J Comp Neurol, 2000 Jul 3. PMID 10861519
    4. MiR-138 promotes the migration of cultured chicken embryonic hypothalamic cells by targeting reelin. Kisliouk T, et al. Neuroscience, 2013 May 15. PMID 23438760
    5. The early isoform of disabled-1 functions independently of Reelin-mediated tyrosine phosphorylation in chick retina. Gao Z, et al. Mol Cell Biol, 2010 Sep. PMID 20606009, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Suggest role for reelin/DAB-1 signaling promoting chondrogenic differentiation of digit mesodermal progenitors in embryonic limbs.
      Title: Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
    2. Reelin, which is expressed in theca cells, triggers a signal in granulosa cells via apolipoprotein E receptor 2 and the very low density lipoprotein receptor
      Title: Signaling by the extracellular matrix protein Reelin promotes granulosa cell proliferation in the chicken follicle.
    3. Reelin activates canonical survival pathways in the limb mesoderm involving protein kinase B and focal adhesion kinase.
      Title: Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix.
    4. Reelin/Dab-1 signaling regulates chondrogenic differentiation of digit progenitors. Reelin is highly expressed in digit cartilages and at more moderate levels in the tendinous blastemas.
      Title: Reelin/DAB-1 signaling in the embryonic limb regulates the chondrogenic differentiation of digit mesodermal progenitors.
    5. These findings describe miR-138 as a novel regulator of hypothalamic cell migration, acting at least in part via inhibition of reelin expression and leading to the inactivation of reelin signals.
      Title: MiR-138 promotes the migration of cultured chicken embryonic hypothalamic cells by targeting reelin.
    6. Reelin is present in the extracellular matrix of the interdigital mesoderm of chick embryo during the developmental stages of digit formation. Reelin expression becomes intensely downregulated preceding the establishment of the areas of interdigital cell death. Gene silencing experiments of Reelin gene confirmed the implication of Reelin signaling as a survival factor for the limb undifferentiated mesoderm.
      Title: Interdigital cell death in the embryonic limb is associated with depletion of Reelin in the extracellular matrix.
    7. The spatiotemporal pattern of Reelin expression, along with the inhibition of sympathetic preganglionic neuron (SPN) migration by exogenous Reelin, suggests that Reelin functions as a barrier to SPN migration during normal development of the spinal cord.
      Title: Reelin inhibits migration of sympathetic preganglionic neurons in the spinal cord of the chick.
    8. In contrast to DAB1-L, which is tyrosine phosphorylated upon Reelin stimulation, DAB1-E is not tyrosine phosphorylated and may function independently of Reelin.
      Title: The early isoform of disabled-1 functions independently of Reelin-mediated tyrosine phosphorylation in chick retina.
    9. A broad distribution of the reelin protein, its mRNA and the mRNAs encoding for the reelin receptors (VLDLR and ApoER2) as well as for its intracellular signaling protein, Disabled1.
      Title: Expression of reelin, its receptors and its intracellular signaling protein, Disabled1 in the canary brain: relationships with the song control system.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in central nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    reelin
    Names
    reelin, extracellular

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305123.2 → NP_001292052.2  reelin precursor

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012
      UniProtKB/TrEMBL
      A0A8V0Y3D5, A0A8V0YC36
      Related
      ENSGALP00010013468.1, ENSGALT00010023277.1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13244082..13517140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004934740.5 → XP_004934797.3  reelin isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y529, A0A8V0YC36
      Related
      ENSGALP00010013476.1, ENSGALT00010023316.1
      Conserved Domains (21) summary
      cd10036
      Location:203 → 352
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:527 → 672
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:868 → 1035
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1241 → 1411
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1607 → 1776
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1958 → 2132
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2324 → 2480
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2671 → 2855
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3057 → 3231
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:709 → 863
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1066 → 1221
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1449 → 1599
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1802 → 1939
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2167 → 2316
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2516 → 2663
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2891 → 3052
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3268 → 3428
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:423 → 557
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd00054
      Location:2134 → 2162
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd08544
      Location:49 → 179
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3233 → 3261
      EGF_Tenascin; Tenascin EGF domain

    2. XM_040701261.2 → XP_040557195.1  reelin isoform X1

      UniProtKB/TrEMBL
      A0A8V0YC36
      Conserved Domains (21) summary
      cd10036
      Location:203 → 352
      Reelin_subrepeat_Nt; Additional N-terminal subrepeat of reelin
      cd10037
      Location:527 → 672
      Reelin_repeat_1_subrepeat_1; N-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10038
      Location:868 → 1035
      Reelin_repeat_2_subrepeat_1; N-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10039
      Location:1241 → 1411
      Reelin_repeat_3_subrepeat_1; N-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10040
      Location:1607 → 1776
      Reelin_repeat_4_subrepeat_1; N-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10041
      Location:1958 → 2132
      Reelin_repeat_5_subrepeat_1; N-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10042
      Location:2324 → 2480
      Reelin_repeat_6_subrepeat_1; N-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10043
      Location:2671 → 2855
      Reelin_repeat_7_subrepeat_1; N-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10044
      Location:3057 → 3231
      Reelin_repeat_8_subrepeat_1; N-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cd10045
      Location:709 → 863
      Reelin_repeat_1_subrepeat_2; C-terminal subrepeat of tandem repeat unit 1 of reelin and related proteins
      cd10046
      Location:1066 → 1221
      Reelin_repeat_2_subrepeat_2; C-terminal subrepeat of tandem repeat unit 2 of reelin and related proteins
      cd10047
      Location:1449 → 1599
      Reelin_repeat_3_subrepeat_2; C-terminal subrepeat of tandem repeat unit 3 of reelin and related proteins
      cd10048
      Location:1802 → 1939
      Reelin_repeat_4_subrepeat_2; C-terminal subrepeat of tandem repeat unit 4 of reelin and related proteins
      cd10049
      Location:2167 → 2316
      Reelin_repeat_5_subrepeat_2; C-terminal subrepeat of tandem repeat unit 5 of reelin and related proteins
      cd10050
      Location:2516 → 2663
      Reelin_repeat_6_subrepeat_2; C-terminal subrepeat of tandem repeat unit 6 of reelin and related proteins
      cd10051
      Location:2891 → 3052
      Reelin_repeat_7_subrepeat_2; C-terminal subrepeat of tandem repeat unit 7 of reelin and related proteins
      cd10052
      Location:3268 → 3428
      Reelin_repeat_8_subrepeat_2; C-terminal subrepeat of tandem repeat unit 8 of reelin and related proteins
      cl15240
      Location:423 → 557
      Reelin_subrepeat_like; Tandem repeat subunit of reelin and related proteins
      cd00054
      Location:2134 → 2162
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd08544
      Location:49 → 179
      Reeler; the N-terminal domain of reelin, F-spondin, and a variety of other proteins
      pfam18720
      Location:3233 → 3261
      EGF_Tenascin; Tenascin EGF domain

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13381349..13654420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046908547.1 → XP_046764503.1  reelin isoform X2

      UniProtKB/TrEMBL
      A0A8V0Y529, A0A8V0YC36

    2. XM_046908546.1 → XP_046764502.1  reelin isoform X1

      UniProtKB/TrEMBL
      A0A8V0YC36
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O93574.1 GenPept UniProtKB/Swiss-Prot:O93574

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials