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    SLC26A5 solute carrier family 26 member 5 [ Gallus gallus (chicken) ]

    Gene ID: 417715, updated on 3-Dec-2024

    Summary

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    Symbol
    SLC26A5provided by CGNC
    Full Name
    solute carrier family 26 member 5provided by CGNC
    Primary source
    CGNC:6231
    See related
    Ensembl:ENSGALG00010009677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SLC26A5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (13201561..13236297, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (13338715..13373564, complement)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene DnaJ heat shock protein family (Hsp40) member C2 Neighboring gene uncharacterized LOC112533002 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene reelin Neighboring gene uncharacterized LOC124417187 Neighboring gene origin recognition complex subunit 5 Neighboring gene transfer RNA glycine (anticodon CCC)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin. Tan X, et al. J Cell Sci, 2012 Feb 15. PMID 22399806, Free PMC Article
    2. From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells. Tan X, et al. J Neurophysiol, 2011 Jan. PMID 21047933, Free PMC Article
    3. Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers. Schaechinger TJ, et al. Proc Natl Acad Sci U S A, 2007 May 1. PMID 17442754, Free PMC Article
    4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. results show, for the first time, that the substitution of a span of 11 amino acid residues confers the electrogenic anion transporters of zebrafish and chicken prestins with motor-like function
      Title: A motif of eleven amino acids is a structural adaptation that facilitates motor capability of eutherian prestin.
    2. Motor function is an innovation of therian prestin and is concurrent with diminished transporter capabilities.
      Title: From zebrafish to mammal: functional evolution of prestin, the motor protein of cochlear outer hair cells.
    3. sequence conservation between mammalian and nonmammalian prestin together with a common pharmacology of electromotility and divalent antiport
      Title: Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables bicarbonate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables chloride transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxalate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables secondary active sulfate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    prestin
    Names
    solute carrier family 26 (anion exchanger), member 5
    solute carrier family 26, member 5 (prestin)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001079477.2 → NP_001072945.1  prestin

      See identical proteins and their annotated locations for NP_001072945.1

      Status: VALIDATED

      Source sequence(s)
      EF028087, JAENSK010000012
      UniProtKB/Swiss-Prot
      A0FKN5, F1NDS6
      UniProtKB/TrEMBL
      A0A8V0XYK1
      Conserved Domains (1) summary
      TIGR00815
      Location:67 → 724
      sulP; high affinity sulphate transporter 1

    2. NM_001397010.1 → NP_001383939.1  prestin

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000012
      UniProtKB/Swiss-Prot
      A0FKN5, F1NDS6
      UniProtKB/TrEMBL
      A0A8V0XYK1
      Related
      ENSGALP00010013367.1, ENSGALT00010023102.1
      Conserved Domains (1) summary
      TIGR00815
      Location:67 → 724
      sulP; high affinity sulphate transporter 1

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      13201561..13236297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932049.1 → XP_046788005.1  prestin isoform X5

      UniProtKB/Swiss-Prot
      A0FKN5, F1NDS6
      UniProtKB/TrEMBL
      A0A8V0XYK1

    2. XM_046931916.1 → XP_046787872.1  prestin isoform X2

      UniProtKB/TrEMBL
      A0A8V0XYK1, A0A8V0Y725
      Related
      ENSGALP00010013370.1, ENSGALT00010023108.1

    3. XM_046931840.1 → XP_046787796.1  prestin isoform X1

      UniProtKB/TrEMBL
      A0A8V0XYK1, A0A8V0Y720
      Related
      ENSGALP00010013365.1, ENSGALT00010023097.1

    4. XM_046931969.1 → XP_046787925.1  prestin isoform X3

      UniProtKB/TrEMBL
      A0A8V0XYJ6, A0A8V0XYK1
      Related
      ENSGALP00010013362.1, ENSGALT00010023093.1

    5. XM_046932023.1 → XP_046787979.1  prestin isoform X4

      UniProtKB/TrEMBL
      A0A8V0XYK1

    6. XM_046932070.1 → XP_046788026.1  prestin isoform X6

      UniProtKB/TrEMBL
      A0A8V0XYK1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      13338715..13373564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046907073.1 → XP_046763029.1  prestin isoform X5

      UniProtKB/Swiss-Prot
      A0FKN5, F1NDS6
      UniProtKB/TrEMBL
      A0A8V0XYK1

    2. XM_046907074.1 → XP_046763030.1  prestin isoform X5

      UniProtKB/Swiss-Prot
      A0FKN5, F1NDS6
      UniProtKB/TrEMBL
      A0A8V0XYK1

    3. XM_046907070.1 → XP_046763026.1  prestin isoform X1

      UniProtKB/TrEMBL
      A0A8V0XYK1, A0A8V0Y720

    4. XM_046907071.1 → XP_046763027.1  prestin isoform X3

      UniProtKB/TrEMBL
      A0A8V0XYJ6, A0A8V0XYK1

    5. XM_046907072.1 → XP_046763028.1  prestin isoform X4

      UniProtKB/TrEMBL
      A0A8V0XYK1

    6. XM_046907075.1 → XP_046763031.1  prestin isoform X6

      UniProtKB/TrEMBL
      A0A8V0XYK1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0FKN5.1 GenPept UniProtKB/Swiss-Prot:A0FKN5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials