CHEK1 checkpoint kinase 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CHEK1provided by CGNC
Full Name: checkpoint kinase 1provided by CGNC
Primary source: CGNC:49106
See related: Ensembl:ENSGALG00010023828
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 24

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	24	NC_052555.1 (431388..435181, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	24	NC_052596.1 (391106..394902, complement)

Chromosome 24 - NC_052555.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that MDV disables the ATR-Chk1 pathway through STAT3 activation to benefit its replication.
Title: Marek's Disease Virus Disables the ATR-Chk1 Pathway by Activating STAT3.
Pericentriolar material expansion depended on CHK1 kinase. Nuclear CHK1 activation after DNA damage mirrored PCM expansion, suggesting a PCM/damage feedback loop whereby CHK1 regulates pericentrin-dependent PCM expansion to control its own activation.
Title: Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response.
BRCA1 promotes G2 arrest and cell death by prolonging phosphorylation of Chk1 on serine 345 after DNA damage to sustain arrest.
Title: BRCA1 Is Required for Maintenance of Phospho-Chk1 and G2/M Arrest during DNA Cross-Link Repair in DT40 Cells.
Chk1 signalling causes centrosome amplification after ionizing radiation by upregulating Cdk2 activity through activating phosphorylation.
Title: DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2.
Results show that S345 phosphorylation is impaired in Chk1 S317A and S366A mutants, suggesting that modification of adjacent SQ sites promotes this key regulatory event.
Title: Chk1 C-terminal regulatory phosphorylation mediates checkpoint activation by de-repression of Chk1 catalytic activity.
Chk1 appears to help defend genomic integrity through effects on several other pathways, including Fanconi anemia proteins, the mitotic spindle, and transcription of cell cycle-related genes [review]
Title: Expanded roles for Chk1 in genome maintenance.
Chk1-dependent centrosome amplification in response to DNA alkylation damage.
Title: DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage.
Inhibition of checkpoint kinase 1 (Chk1) by RNA-mediated interference or drug treatment suppressed DNA-damage-induced centrosome amplification.
Title: DNA damage induces Chk1-dependent centrosome amplification.
These results suggest a mechanism through which Chk1 could protect against tumorigenesis through its role in spindle checkpoint signaling.
Title: Chk1 is required for spindle checkpoint function.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serine/threonine-protein kinase Chk1

Names: CHK1 checkpoint homolog; STT3, subunit of the oligosaccharyltransferase complex, homolog A; integral membrane protein 1

NP_989676.1

EC 2.7.11.1

XP_015153427.1

EC 2.7.11.1

XP_046788207.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204345.2 → NP_989676.1 serine/threonine-protein kinase Chk1

See identical proteins and their annotated locations for NP_989676.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000341

UniProtKB/Swiss-Prot

Q8AYC9

UniProtKB/TrEMBL

A0A8V0ZPA5

Related

ENSGALP00010035254.1, ENSGALT00010058076.1

Conserved Domains (1) summary

cd14069
Location:7 → 265

STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052555.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

431388..435181 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015297941.4 → XP_015153427.1 serine/threonine-protein kinase Chk1 isoform X1

UniProtKB/TrEMBL

A0A8V0ZPA5

Conserved Domains (2) summary

smart00220
Location:9 → 264

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14069
Location:7 → 265

STKc_Chk1; Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1