GRB10 growth factor receptor bound protein 10 [Gallus gallus (chicken)] - Gene

Summary

Symbol: GRB10provided by CGNC
Full Name: growth factor receptor bound protein 10provided by CGNC
Primary source: CGNC:9904
See related: Ensembl:ENSGALG00010000674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (80480880..80622632, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (80530396..80638101, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables insulin receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: growth factor receptor-bound protein 10

Names: adapter protein; binds to insulin receptor and IGF1R

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039282.4 → NP_001034371.2 growth factor receptor-bound protein 10

Status: VALIDATED

Source sequence(s)

JAENSK010000041

UniProtKB/TrEMBL

A0A1D5P405, Q5QJU5

Conserved Domains (4) summary

cd10415
Location:489 → 596

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:288 → 410

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:167 → 257

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:428 → 469

BPS; BPS (Between PH and SH2)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

80480880..80622632 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025147273.3 → XP_025003041.1 growth factor receptor-bound protein 10 isoform X1

UniProtKB/TrEMBL

A0A1D5P405, Q5QJU5

Related

ENSGALP00010000762.1, ENSGALT00010001417.1

Conserved Domains (4) summary

cd10415
Location:489 → 596

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:288 → 410

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:167 → 257

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:428 → 469

BPS; BPS (Between PH and SH2)
XM_015282308.4 → XP_015137794.1 growth factor receptor-bound protein 10 isoform X1

UniProtKB/TrEMBL

A0A1D5P405, Q5QJU5

Conserved Domains (4) summary

cd10415
Location:489 → 596

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:288 → 410

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:167 → 257

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:428 → 469

BPS; BPS (Between PH and SH2)
XM_046924477.1 → XP_046780433.1 growth factor receptor-bound protein 10 isoform X1

UniProtKB/TrEMBL

A0A1D5P405, Q5QJU5
XM_015282309.4 → XP_015137795.1 growth factor receptor-bound protein 10 isoform X3

UniProtKB/TrEMBL

A0A8V0X5W7, Q5QJU5

Related

ENSGALP00010000763.1, ENSGALT00010001420.1

Conserved Domains (4) summary

cd01787
Location:167 → 248

GRB7_RA; RA (RAS-associated like) domain of Grb7

cd10415
Location:450 → 557

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:288 → 410

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

pfam00169
Location:293 → 401

PH; PH domain
XM_040684208.2 → XP_040540142.1 growth factor receptor-bound protein 10 isoform X1

UniProtKB/TrEMBL

A0A1D5P405, Q5QJU5

Conserved Domains (4) summary

cd10415
Location:489 → 596

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:288 → 410

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:167 → 257

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10

pfam08947
Location:428 → 469

BPS; BPS (Between PH and SH2)
XM_040684209.2 → XP_040540143.1 growth factor receptor-bound protein 10 isoform X4

UniProtKB/TrEMBL

Q5QJU5

Conserved Domains (3) summary

cd10415
Location:447 → 554

SH2_Grb10; Src homology 2 (SH2) domain found in the growth factor receptor bound, subclass 10 (Grb10) proteins

cd01259
Location:246 → 368

PH_APBB1IP; Amyloid beta (A4) Precursor protein-Binding, family B, member 1 Interacting Protein pleckstrin homology (PH) domain

cd16141
Location:125 → 215

RA_GRB10; Ras-associating (RA) domain found in growth factor receptor-bound (Grb) protein 10
XM_046924480.1 → XP_046780436.1 growth factor receptor-bound protein 10 isoform X2

UniProtKB/TrEMBL

A0A8V0X3H6, Q5QJU5

Related

ENSGALP00010000760.1, ENSGALT00010001412.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

80530396..80638101 complement

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GenBank, FASTA, Sequence Viewer (Graphics)