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    GABRA4 gamma-aminobutyric acid type A receptor alpha4 subunit [ Gallus gallus (chicken) ]

    Gene ID: 422770, updated on 3-Dec-2024

    Summary

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    Symbol
    GABRA4provided by CGNC
    Full Name
    gamma-aminobutyric acid type A receptor alpha4 subunitprovided by CGNC
    Primary source
    CGNC:10586
    See related
    Ensembl:ENSGALG00010013661
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See GABRA4 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (66448723..66494727)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (66432810..66478816)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene gamma-aminobutyric acid receptor subunit beta-1 Neighboring gene COMM domain containing 8 Neighboring gene uncharacterized LOC107053242 Neighboring gene bcl-2-binding component 3 Neighboring gene uncharacterized LOC124417971 Neighboring gene gamma-aminobutyric acid type A receptor alpha2 subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables GABA-gated chloride ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables benzodiazepine receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables inhibitory extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic transmission, GABAergic IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GABA-A receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in dendrite membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gamma-aminobutyric acid receptor subunit alpha-4
    Names
    gamma-aminobutyric acid (GABA) A receptor, alpha 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      66448723..66494727
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004936058.5 → XP_004936115.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YF30, A0A8V0YKW6
      Related
      ENSGALP00010019443.1, ENSGALT00010032830.1
      Conserved Domains (3) summary
      TIGR00860
      Location:50 → 561
      LIC; Cation transporter family protein
      cd03558
      Location:191 → 205
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:56 → 274
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    2. XM_420724.8 → XP_420724.2  gamma-aminobutyric acid receptor subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF30
      Related
      ENSGALP00010019444.1, ENSGALT00010032831.1
      Conserved Domains (3) summary
      TIGR00860
      Location:50 → 541
      LIC; Cation transporter family protein
      cd03558
      Location:171 → 185
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:56 → 254
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    3. XM_046941223.1 → XP_046797179.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YF30

    4. XM_040700260.2 → XP_040556194.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YF30
      Conserved Domains (3) summary
      TIGR00860
      Location:1 → 452
      LIC; Cation transporter family protein
      cd03558
      Location:82 → 96
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1 → 165
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      66432810..66478816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040671644.2 → XP_040527578.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YF30, A0A8V0YKW6
      Conserved Domains (3) summary
      TIGR00860
      Location:50 → 561
      LIC; Cation transporter family protein
      cd03558
      Location:191 → 205
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:56 → 274
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    2. XM_040671645.2 → XP_040527579.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF30
      Conserved Domains (3) summary
      TIGR00860
      Location:50 → 541
      LIC; Cation transporter family protein
      cd03558
      Location:171 → 185
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:56 → 254
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))

    3. XM_046917532.1 → XP_046773488.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YF30

    4. XM_040671646.2 → XP_040527580.1  gamma-aminobutyric acid receptor subunit alpha-4 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YF30
      Conserved Domains (3) summary
      TIGR00860
      Location:1 → 452
      LIC; Cation transporter family protein
      cd03558
      Location:82 → 96
      LGIC_ECD; Cys-loop [structural motif]
      cl28912
      Location:1 → 165
      LGIC_ECD; extracellular domain (ECD) of Cys-loop neurotransmitter-gated ion channels (also known as ligand-gated ion channel (LGIC))
    Nucleotide Protein
    Heading Accession and Version

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