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    HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 [ Gallus gallus (chicken) ]

    Gene ID: 421788, updated on 3-Dec-2024

    Summary

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    Symbol
    HACE1provided by CGNC
    Full Name
    HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1provided by CGNC
    Primary source
    CGNC:11486
    See related
    Ensembl:ENSGALG00010012419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See HACE1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (68714168..68758254)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (68494564..68538780)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene blood vessel epicardial substance Neighboring gene lin-28 homolog B Neighboring gene uncharacterized LOC101751157 Neighboring gene uncharacterized LOC121113177

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase HACE1
    Names
    HECT-type E3 ubiquitin transferase HACE1
    NP_001265084.1
    XP_015140015.1
    XP_015140016.1
    XP_046770007.1
    XP_046770008.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278155.2 → NP_001265084.1  E3 ubiquitin-protein ligase HACE1

      See identical proteins and their annotated locations for NP_001265084.1

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000065
      UniProtKB/Swiss-Prot
      E1C656, Q5F340
      UniProtKB/TrEMBL
      A0A8V0YFN8
      Related
      ENSGALP00010017338.1, ENSGALT00010029779.1
      Conserved Domains (4) summary
      cd00078
      Location:587 → 936
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:92 → 217
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:97 → 128
      ANK; ANK repeat [structural motif]
      cl26073
      Location:27 → 283
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      68714168..68758254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015284529.4 → XP_015140015.1  E3 ubiquitin-protein ligase HACE1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YEH7
      Related
      ENSGALP00010017325.1, ENSGALT00010029763.1
      Conserved Domains (4) summary
      cd00078
      Location:555 → 904
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:92 → 217
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:97 → 128
      ANK; ANK repeat [structural motif]
      cl26073
      Location:27 → 283
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_015284530.3 → XP_015140016.1  E3 ubiquitin-protein ligase HACE1 isoform X2

      Conserved Domains (3) summary
      cd00078
      Location:474 → 823
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      cd00204
      Location:12 → 136
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00045
      Location:17 → 48
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_003074228.3 RNA Sequence

      Related
      ENSGALT00010029751.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      68494564..68538780
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046914051.1 → XP_046770007.1  E3 ubiquitin-protein ligase HACE1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YEH7

    2. XM_046914052.1 → XP_046770008.1  E3 ubiquitin-protein ligase HACE1 isoform X2

    RNA

    1. XR_006933966.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001031078.1: Suppressed sequence

      Description
      NM_001031078.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1C656.1 GenPept UniProtKB/Swiss-Prot:E1C656

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.