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    Lmbr1l limb region 1 like [ Mus musculus (house mouse) ]

    Gene ID: 74775, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lmbr1lprovided by MGI
    Official Full Name
    limb region 1 likeprovided by MGI
    Primary source
    MGI:MGI:1289247
    See related
    Ensembl:ENSMUSG00000022999 AllianceGenome:MGI:1289247
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Limr; D15Ertd735e; 1110013E13Rik
    Summary
    Predicted to enable transmembrane signaling receptor activity. Involved in several processes, including T cell activation; hematopoietic stem cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LMBR1L (limb development membrane protein 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 85.7), thymus adult (RPKM 30.7) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lmbr1l in Genome Data Viewer
    Location:
    15 F1; 15 55.1 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (98801798..98815944, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (98903918..98918098, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10880 Neighboring gene Ras homolog enriched in brain like 1 Neighboring gene desert hedgehog Neighboring gene STARR-positive B cell enhancer mm9_chr15:98748573-98748874 Neighboring gene predicted gene, 41396 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98764367-98764476 Neighboring gene tubulin, alpha 1B Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:98783649-98783758 Neighboring gene STARR-positive B cell enhancer ABC_E7416 Neighboring gene tubulin, alpha 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/β-catenin signaling. Liu W, et al. J Cell Sci, 2022 Mar 15. PMID 35146515
    2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    3. LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling. Choi JH, et al. Science, 2019 May 10. PMID 31073040, Free PMC Article
    4. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/beta-catenin signaling.
      Title: LMBR1L regulates the proliferation and migration of endothelial cells through Norrin/β-catenin signaling.
    2. LMBR1L has an essential function during lymphopoiesis and lymphoid activation, acting as a negative regulator of the Wnt/beta-catenin pathway.
      Title: LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in T cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hematopoietic stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor-mediated endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor-mediated endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in receptor-mediated endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein LMBR1L
    Names
    lipocalin-1-interacting membrane receptor
    lipocalin-interacting membrane receptor
    uteroglobin receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418770.1 → NP_001405699.1  protein LMBR1L isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC161165

    2. NM_001418771.1 → NP_001405700.1  protein LMBR1L isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC161165

    3. NM_029098.4 → NP_083374.1  protein LMBR1L isoform 1

      See identical proteins and their annotated locations for NP_083374.1

      Status: VALIDATED

      Source sequence(s)
      AC161165
      Consensus CDS
      CCDS27811.1
      UniProtKB/Swiss-Prot
      Q3TD82, Q69ZP7, Q9D1E5
      Related
      ENSMUSP00000023736.9, ENSMUST00000023736.10
      Conserved Domains (1) summary
      pfam04791
      Location:21 → 452
      LMBR1; LMBR1-like membrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      98801798..98815944 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248804.2 → XP_030104664.1  protein LMBR1L isoform X1

      Conserved Domains (1) summary
      pfam04791
      Location:24 → 451
      LMBR1; LMBR1-like membrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D1E5.1 GenPept UniProtKB/Swiss-Prot:Q9D1E5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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