pdcl3 phosducin-like 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pdcl3provided by ZNC
Official Full Name: phosducin-like 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040322-1
See related: AllianceGenome:ZFIN:ZDB-GENE-040322-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: viaf1; zgc:73170
Summary: Predicted to enable protein folding chaperone and vascular endothelial growth factor receptor 2 binding activity. Involved in positive regulation of gene expression. Acts upstream of or within angiogenesis. Predicted to be located in endoplasmic reticulum and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Un

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	Unplaced Scaffold	NW_003337220.1 (2003..10128)
105	previous assembly	GRCz10 (GCF_000002035.5)	Unplaced Scaffold	NW_003337220.1 (2003..10128)

NW_003337220.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb37b03.x1 (e-PCR)
- UniSTS:190505

fb37b03.x1 (e-PCR)
- UniSTS:190506

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosducin-like protein 3

Names: IAP-associated factor Viaf1; VIAF; viral IAP-associated factor 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205721.1 → NP_991284.1 phosducin-like protein 3

See identical proteins and their annotated locations for NP_991284.1

Status: PROVISIONAL

Source sequence(s)

BC064706

UniProtKB/Swiss-Prot

Q6P268, Q800E3

Conserved Domains (1) summary

cd02988
Location:8 → 200

Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...