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    acta1a actin alpha 1, skeletal muscle a [ Danio rerio (zebrafish) ]

    Gene ID: 550445, updated on 5-Jan-2025

    Summary

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    Official Symbol
    acta1aprovided by ZNC
    Official Full Name
    actin alpha 1, skeletal muscle aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-267
    See related
    Ensembl:ENSDARG00000036371 AllianceGenome:ZFIN:ZDB-GENE-050417-267
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zeh0293; hm:zeh0293; zgc:112098
    Summary
    Acts upstream of or within skeletal muscle fiber development. Predicted to be active in actin cytoskeleton. Is expressed in several structures, including adaxial cell; fin; musculature system; pericardial region; and trunk. Human ortholog(s) of this gene implicated in congenital myopathy 2B; congenital myopathy 2C; and nemaline myopathy 3. Orthologous to human ACTA1 (actin alpha 1, skeletal muscle). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

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    See acta1a in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (53945959..53953532)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (53286216..53293789)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene calpain 9 Neighboring gene TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor Neighboring gene nucleoporin 133 Neighboring gene centriole, cilia and spindle-associated protein a Neighboring gene si:ch211-133l11.10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. In vivo glucose imaging in multiple model organisms with an engineered single-wavelength sensor. Keller JP, et al. Cell Rep, 2021 Jun 22. PMID 34161775
    2. RNA sequencing to study gene expression and SNP variations associated with growth in zebrafish fed a plant protein-based diet. Ulloa PE, et al. Mar Biotechnol (NY), 2015 Jun. PMID 25702041
    3. Zebrafish models for nemaline myopathy reveal a spectrum of nemaline bodies contributing to reduced muscle function. Sztal TE, et al. Acta Neuropathol, 2015 Sep. PMID 25931053, Free PMC Article
    4. A comparative study of ryanodine receptor (RyR) gene expression levels in a basal ray-finned fish, bichir (Polypterus ornatipinnis) and the derived euteleost zebrafish (Danio rerio). Darbandi S, et al. Comp Biochem Physiol B Biochem Mol Biol, 2009 Dec. PMID 19755169
    5. Downregulation of GSTK1 Is a Common Mechanism Underlying Hypertrophic Cardiomyopathy. Sasagawa S, et al. Front Pharmacol, 2016. PMID 27378925, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within skeletal muscle fiber development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin alpha 1, skeletal muscle a
    Names
    actin, alpha 1a, skeletal muscle

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017750.1 → NP_001017750.1  actin alpha 1, skeletal muscle a

      See identical proteins and their annotated locations for NP_001017750.1

      Status: PROVISIONAL

      Source sequence(s)
      BC093200
      UniProtKB/TrEMBL
      Q567E8
      Related
      ENSDARP00000052837.4, ENSDART00000052838.5
      Conserved Domains (2) summary
      smart00268
      Location:7 → 377
      ACTIN; Actin
      cl17037
      Location:4 → 377
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      53945959..53953532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068219246.1 → XP_068075347.1  actin alpha 1, skeletal muscle a isoform X1

    Nucleotide Protein
    Heading Accession and Version

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