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    Cdkn3 cyclin dependent kinase inhibitor 3 [ Mus musculus (house mouse) ]

    Gene ID: 72391, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdkn3provided by MGI
    Official Full Name
    cyclin dependent kinase inhibitor 3provided by MGI
    Primary source
    MGI:MGI:1919641
    See related
    Ensembl:ENSMUSG00000037628 AllianceGenome:MGI:1919641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAP; 2410006H10Rik
    Summary
    Predicted to enable protein serine/threonine phosphatase activity and protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to act upstream of or within DNA damage response and regulation of cell cycle. Predicted to be located in cytosol and perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in axial skeleton; cerebral cortex; cranium; hindlimb long bone; and pelvic girdle skeleton. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CDKN3 (cyclin dependent kinase inhibitor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 55.4), liver E14 (RPKM 19.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdkn3 in Genome Data Viewer
    Location:
    14 24.28 cM; 14 C1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (46997912..47008987)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (46760461..46771530)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933425B07 gene Neighboring gene predicted gene, 41146 Neighboring gene RIKEN cDNA D330046F09 gene Neighboring gene STARR-seq mESC enhancer starr_36562 Neighboring gene STARR-seq mESC enhancer starr_36563 Neighboring gene STARR-positive B cell enhancer ABC_E752 Neighboring gene cornichon family AMPA receptor auxiliary protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E7306 Neighboring gene glia maturation factor, beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling. Yu C, et al. Biomed Pharmacother, 2017 Dec. PMID 29196103
    2. The cell cycle associated protein, HTm4, is expressed in differentiating cells of the hematopoietic and central nervous system in mice. Kutok JL, et al. J Mol Histol, 2005 Feb. PMID 15704002
    3. Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis. Zhang M, et al. Artif Cells Nanomed Biotechnol, 2019 Dec. PMID 31352814
    4. Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice. Tan L, et al. Front Cell Dev Biol, 2021. PMID 33681192, Free PMC Article
    5. PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. Khoury-Haddad H, et al. Proc Natl Acad Sci U S A, 2014 Feb 18. PMID 24550317, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NEAT1 may exert a protective effect on HUVECs by regulating the miR-181d-5p/CDKN3A axis
      Title: Long non-coding RNA NEAT1 inhibits oxidative stress-induced vascular endothelial cell injury by activating the miR-181d-5p/CDKN3 axis.
    2. Knockdown of CDKN3 expression inhibited prostate cancer tumor growth in the nude mouse model.
      Title: Cyclin-dependent kinase inhibitor 3 (CDKN3) plays a critical role in prostate cancer via regulating cell cycle and DNA replication signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP kinase serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS140 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine/threonine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-dependent kinase inhibitor 3
    Names
    CDK2-associated dual-specificity phosphatase
    kinase-associated phosphatase
    NP_001346970.1
    NP_082498.1
    XP_006519656.1
    XP_006519657.1
    XP_030103904.1
    XP_036014748.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360041.1 → NP_001346970.1  cyclin-dependent kinase inhibitor 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AA218046, AA510251, BY084534
      Related
      ENSMUST00000226621.2
      Conserved Domains (1) summary
      pfam05706
      Location:1 → 168
      CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

    2. NM_028222.2 → NP_082498.1  cyclin-dependent kinase inhibitor 3 isoform 2

      See identical proteins and their annotated locations for NP_082498.1

      Status: VALIDATED

      Source sequence(s)
      AA218046, BC049694, BY084534
      Consensus CDS
      CCDS49466.1
      UniProtKB/Swiss-Prot
      Q810P3, Q9CWS3
      Related
      ENSMUSP00000070575.5, ENSMUST00000067426.6
      Conserved Domains (1) summary
      pfam05706
      Location:1 → 167
      CDKN3; Cyclin-dependent kinase inhibitor 3 (CDKN3)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      46997912..47008987
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158855.1 → XP_036014748.1  cyclin-dependent kinase inhibitor 3 isoform X1

      UniProtKB/TrEMBL
      A0A2I3BPS7
      Related
      ENSMUSP00000154120.2, ENSMUST00000228106.2
      Conserved Domains (1) summary
      cl28904
      Location:1 → 139
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    2. XM_030248044.1 → XP_030103904.1  cyclin-dependent kinase inhibitor 3 isoform X3

      Conserved Domains (1) summary
      cl28904
      Location:17 → 153
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    3. XM_006519594.4 → XP_006519657.1  cyclin-dependent kinase inhibitor 3 isoform X2

      See identical proteins and their annotated locations for XP_006519657.1

      Conserved Domains (1) summary
      cl28904
      Location:17 → 154
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

    4. XM_006519593.3 → XP_006519656.1  cyclin-dependent kinase inhibitor 3 isoform X2

      See identical proteins and their annotated locations for XP_006519656.1

      Conserved Domains (1) summary
      cl28904
      Location:17 → 154
      PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810P3.1 GenPept UniProtKB/Swiss-Prot:Q810P3

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    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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