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    fbxo-11.2 UBR-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 182047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fbxo-11.2
    Official Full Name
    UBR-type domain-containing protein
    Primary source
    WormBase:WBGene00015268
    Locus tag
    CELE_BE0003N10.3
    See related
    AllianceGenome:WB:WBGene00015268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable zinc ion binding activity. Human ortholog(s) of this gene implicated in breast carcinoma and lung non-small cell carcinoma. Orthologous to human FBXO11 (F-box protein 11). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fbxo-11.2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003281.10 (1046261..1053242, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene polyribonucleotide nucleotidyltransferase Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Methyltransf_21 domain-containing protein;Methyltransferase FkbM domain-containing protein Neighboring gene Splicing factor U2AF 65 kDa subunit Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A snapshot of the physical and functional wiring of the Eps15 homology domain network in the nematode. Tsushima H, et al. PLoS One, 2013. PMID 23424658, Free PMC Article
    2. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article
    3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    UBR-type domain-containing protein
    NP_001368534.1
    • Confirmed by transcript evidence
    NP_001380182.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      1046261..1053242 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393274.1 → NP_001380182.1  UBR-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AX46
      Conserved Domains (2) summary
      pfam02207
      Location:665 → 706
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam13229
      Location:349 → 495
      Beta_helix; Right handed beta helix region

    2. NM_001381723.1 → NP_001368534.1  UBR-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3ARS9
      Conserved Domains (2) summary
      pfam02207
      Location:603 → 644
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam13229
      Location:287 → 433
      Beta_helix; Right handed beta helix region
    Nucleotide Protein
    Heading Accession and Version

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