dhcr-24 Diminuto-like protein;FAD-binding PCMH-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dhcr-24
Official Full Name: Diminuto-like protein;FAD-binding PCMH-type domain-containing protein
Primary source: WormBase:WBGene00018718
Locus tag: CELE_F52H2.6
See related: AllianceGenome:WB:WBGene00018718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable delta24(24-1) sterol reductase activity. Predicted to be involved in steroid metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in intestine. Human ortholog(s) of this gene implicated in lipid metabolism disorder. Orthologous to human DHCR24 (24-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See dhcr-24 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 7

Sequence:: Chromosome: X; NC_003284.9 (2559711..2564147, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

F52H2.6 (e-PCR)
- UniSTS:311732

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables delta24(24-1) sterol reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables delta24-sterol reductase activity	IEA Inferred from Electronic Annotation more info
enables flavin adenine dinucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Diminuto-like protein;FAD-binding PCMH-type domain-containing protein

NP_001362099.1

Confirmed by transcript evidence

NP_508463.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2559711..2564147 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001374978.3 → NP_001362099.1 FAD-binding PCMH-type domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A5E4LZ56

Conserved Domains (1) summary

pfam01565
Location:61 → 197

FAD_binding_4; FAD binding domain
NM_076062.8 → NP_508463.1 Diminuto-like protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508463.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O17397

Conserved Domains (2) summary

COG0277
Location:109 → 238

GlcD; FAD/FMN-containing dehydrogenase [Energy production and conversion]

pfam01565
Location:61 → 198

FAD_binding_4; FAD binding domain