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    tmed-3 GOLD domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172372, updated on 4-Jan-2025

    Summary

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    Official Symbol
    tmed-3
    Official Full Name
    GOLD domain-containing protein
    Primary source
    WormBase:WBGene00019003
    Locus tag
    CELE_F57B10.5
    See related
    AllianceGenome:WB:WBGene00019003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to several human genes including TMED7-TICAM2 (TMED7-TICAM2 readthrough) and TMED7 (transmembrane p24 trafficking protein 7). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See tmed-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (6562699..6563660)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene XPG (Xeroderma Pigmentosum group G) DNA repair gene homolog Neighboring gene ncRNA Neighboring gene BAG family molecular chaperone regulator 1 Neighboring gene Meiotic spindle formation protein 2 Neighboring gene Protein MRVI1;Thyroid receptor-interacting protein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic characterization of C. elegans TMED genes. Navarro KG, et al. Dev Dyn, 2023 Sep. PMID 37204056, Free PMC Article
    2. Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model. Hamamichi S, et al. Proc Natl Acad Sci U S A, 2008 Jan 15. PMID 18182484, Free PMC Article
    3. Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis. Xiao L, et al. Cell Syst, 2022 Aug 17. PMID 35882226
    4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    5. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GOLD domain-containing protein
    NP_491892.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6562699..6563660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059491.5 → NP_491892.1  GOLD domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491892.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O44738
      Conserved Domains (1) summary
      pfam01105
      Location:19 → 197
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    Nucleotide Protein
    Heading Accession and Version

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