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    chkr-1 CHeckpoint Kinase Related [ Caenorhabditis elegans ]

    Gene ID: 191613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    chkr-1
    Official Full Name
    CHeckpoint Kinase Related
    Primary source
    WormBase:WBGene00011612
    Locus tag
    CELE_T08D2.7
    See related
    AllianceGenome:WB:WBGene00011612
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast cancer (multiple); colorectal cancer; osteosarcoma; and prostate cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See chkr-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    14
    Sequence:
    Chromosome: X; NC_003284.9 (182691..191193)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ING domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene TOG domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. WormGender - Open-Source Software for Automatic Caenorhabditis elegans Sex Ratio Measurement. Labocha MK, et al. PLoS One, 2015. PMID 26421844, Free PMC Article
    2. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitotic DNA damage checkpoint signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CHeckpoint Kinase Related
    NP_508060.1
    • Partially confirmed by transcript evidence;
      Product from WormBase gene class chkr

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      182691..191193
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_075659.2 → NP_508060.1  CHeckpoint Kinase Related [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_508060.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4F324
      Conserved Domains (2) summary
      smart00220
      Location:174 → 435
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:161 → 435
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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