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    nrps-1 Carrier domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 190498, updated on 9-Dec-2024

    Summary

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    Official Symbol
    nrps-1
    Official Full Name
    Carrier domain-containing protein
    Primary source
    WormBase:WBGene00013440
    Locus tag
    CELE_Y66D12A.14
    See related
    AllianceGenome:WB:WBGene00013440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphopantetheine binding activity. Predicted to be involved in amino acid activation for nonribosomal peptide biosynthetic process and secondary metabolite biosynthetic process. Predicted to be active in cytoplasm. Is expressed in CANL and CANR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See nrps-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (11534674..11546712)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Suppressor of spindle checkpoint defect 1 Neighboring gene DUF1604 domain-containing protein;SMAP domain-containing protein;Spen family transcriptional repressor Neighboring gene General transcription and DNA repair factor IIH helicase/translocase subunit XPB Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Phe

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan. Feng L, et al. Nat Commun, 2021 Aug 13. PMID 34389721, Free PMC Article
    2. A hybrid polyketide-nonribosomal peptide in nematodes that promotes larval survival. Shou Q, et al. Nat Chem Biol, 2016 Oct. PMID 27501395, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
      Title: Mapping the biosynthetic pathway of a hybrid polyketide-nonribosomal peptide in a metazoan.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopantetheine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopantetheine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid activation for nonribosomal peptide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in secondary metabolite biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Carrier domain-containing protein
    NP_499488.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      11534674..11546712
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067087.5 → NP_499488.3  Carrier domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499488.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95Q02
      Conserved Domains (5) summary
      TIGR01733
      Location:2253 → 2578
      AA-adenyl-dom; amino acid adenylation domain
      pfam00550
      Location:1712 → 1776
      PP-binding; Phosphopantetheine attachment site
      pfam13745
      Location:712 → 802
      HxxPF_rpt; HxxPF-repeated domain
      cl17068
      Location:2223 → 2641
      AFD_class_I; Adenylate forming domain, Class I superfamily
      cl23853
      Location:441 → 686
      Condensation; Condensation domain
    Nucleotide Protein
    Heading Accession and Version

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