Slc25a47 solute carrier family 25, member 47 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc25a47provided by MGI
Official Full Name: solute carrier family 25, member 47provided by MGI
Primary source: MGI:MGI:2144766
See related: Ensembl:ENSMUSG00000048856 AllianceGenome:MGI:2144766
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HDMCP
Summary: Enables NAD transmembrane transporter activity and acetyl-CoA transmembrane transporter activity. Predicted to be involved in NAD transmembrane transport and acetyl-CoA transport. Located in mitochondrial inner membrane and mitochondrial outer membrane. Is expressed in liver and metanephros. Orthologous to human SLC25A47 (solute carrier family 25 member 47). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 215.8), liver E18 (RPKM 48.5) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 12 F1; 12 59.65 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (108815740..108822741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (108849833..108856815)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKalpha mediating lipid metabolism and tumorigenesis.
Title: Hepatic mitochondrial NAD + transporter SLC25A47 activates AMPKα mediating lipid metabolism and tumorigenesis.
The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
Title: The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis.
Increased HDMCP expression was identified in nonalcoholic steatohepatitis animal model and HFFA-72h cultured L02 cell. Moreover, under regulation of miR-146, nonalcoholic steatohepatitis alleviation was achieved after HDMCP downregulation in both in vivo and in vitro, according to the declination of steatosis and inflammation related markers.
Title: Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis.
hepatocellular carcinoma down-regulated mitochondrial carrier protein is a novel liver-specific uncoupling protein
Title: Cloning and identification of hepatocellular carcinoma down-regulated mitochondrial carrier protein, a novel liver-specific uncoupling protein.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

AI876593 (e-PCR)
- UniSTS:180469

AI132487 (e-PCR)
- UniSTS:160253

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables acetyl-CoA transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in NAD transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 25 member 47

Names: hepatocellular carcinoma down-regulated mitochondrial carrier homolog; mitochondrial NAD(+) transporter SLC25A47; mitochondrial hepatocellular carcinoma-downregulated carrier protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012310.2 → NP_001012310.2 solute carrier family 25 member 47

See identical proteins and their annotated locations for NP_001012310.2

Status: VALIDATED

Source sequence(s)

AI173533, AK149369

Consensus CDS

CCDS26165.1

UniProtKB/Swiss-Prot

Q3UES2, Q5FW58, Q6IS41, Q7TPP3

Related

ENSMUSP00000050329.9, ENSMUST00000057026.10

Conserved Domains (1) summary

pfam00153
Location:215 → 304

Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

108815740..108822741

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243981.4 → XP_011242283.1 solute carrier family 25 member 47 isoform X1

Conserved Domains (1) summary

pfam00153
Location:226 → 307

Mito_carr; Mitochondrial carrier protein