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    Defb42 defensin beta 42 [ Mus musculus (house mouse) ]

    Gene ID: 619548, updated on 9-Dec-2024

    Summary

    Official Symbol
    Defb42provided by MGI
    Official Full Name
    defensin beta 42provided by MGI
    Primary source
    MGI:MGI:3033850
    See related
    Ensembl:ENSMUSG00000054763 AllianceGenome:MGI:3033850
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    BD-42; Defb44; mBD-42
    Summary
    Predicted to enable lipopolysaccharide binding activity. Predicted to be involved in defense response to other organism. Predicted to be located in extracellular region. Orthologous to human DEFB136 (defensin beta 136). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward genital fat pad adult (RPKM 681.0) See more
    Orthologs
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    Genomic context

    See Defb42 in Genome Data Viewer
    Location:
    14 D1; 14 33.24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (63284445..63286052)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (63046991..63048606)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene nuclear undecaprenyl pyrophosphate synthase 1 homolog pseudogene Neighboring gene defensin beta 30 Neighboring gene RIKEN cDNA 2700070H01 gene Neighboring gene STARR-seq mESC enhancer starr_36912 Neighboring gene VISTA enhancer mm244 Neighboring gene predicted gene, 35908

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipopolysaccharide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables lipopolysaccharide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables lipopolysaccharide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in antibacterial innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antibacterial innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antifungal innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in antifungal innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antifungal innate immune response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in defense response to Gram-negative bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in defense response to Gram-positive bacterium IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    beta-defensin 42
    Names
    beta-defensin 136
    beta-defensin 44

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034910.4NP_001030082.1  beta-defensin 42 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090659
      Consensus CDS
      CCDS36948.1
      UniProtKB/Swiss-Prot
      Q4FZ54, Q8BVB5
      Related
      ENSMUSP00000070629.2, ENSMUST00000067990.8
      Conserved Domains (1) summary
      pfam17333
      Location:2575
      DEFB136; Beta-defensin 136
    2. NM_001412580.1NP_001399509.1  beta-defensin 42 precursor

      Status: VALIDATED

      Source sequence(s)
      AC090659
      UniProtKB/Swiss-Prot
      Q4FZ54, Q8BVB5
      Related
      ENSMUSP00000106834.2, ENSMUST00000111203.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      63284445..63286052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)