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    Krt90 keratin 90 [ Mus musculus (house mouse) ]

    Gene ID: 239673, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Krt90provided by MGI
    Official Full Name
    keratin 90provided by MGI
    Primary source
    MGI:MGI:3045312
    See related
    Ensembl:ENSMUSG00000048699 AllianceGenome:MGI:3045312
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ket90; 4732456N10Rik
    Summary
    Predicted to be a structural constituent of skin epidermis. Predicted to be involved in intermediate filament organization and keratinization. Predicted to be active in keratin filament. Orthologous to human KRT90P (keratin 90, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Krt90 in Genome Data Viewer
    Location:
    15 F2; 15 56.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (101460791..101471385, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (101552356..101562950, complement)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39799 Neighboring gene keratin 84 Neighboring gene keratin 82 Neighboring gene keratin 75 Neighboring gene STARR-seq mESC enhancer starr_39800 Neighboring gene type II keratin Kb17P pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Witch Nails (Krt90whnl): A spontaneous mouse mutation affecting nail growth and development. Sundberg JP, et al. PLoS One, 2022. PMID 36374931, Free PMC Article
    2. In vivo dual-tagging proteomic approach in studying signaling pathways in immune response. Wang T, et al. J Proteome Res, 2005 May-Jun. PMID 15952741
    3. Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Fairfield H, et al. Genome Res, 2015 Jul. PMID 25917818, Free PMC Article
    4. The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization. Titz B, et al. Oncogene, 2010 Nov 4. PMID 20697350, Free PMC Article
    5. Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting. Lokireddy S, et al. Am J Physiol Cell Physiol, 2012 Sep 1. PMID 22673621

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Spontaneous (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in keratinization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC239673

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177717.4 → NP_808385.2  uncharacterized protein LOC239673

      Status: VALIDATED

      Source sequence(s)
      AC103674, AK028791
      Consensus CDS
      CCDS27855.1
      UniProtKB/TrEMBL
      E9Q1Z0, Q148Q7
      Related
      ENSMUSP00000023714.5, ENSMUST00000023714.5
      Conserved Domains (4) summary
      pfam00038
      Location:142 → 453
      Filament; Intermediate filament protein
      pfam16208
      Location:16 → 139
      Keratin_2_head; Keratin type II head
      cl01888
      Location:366 → 426
      DUF883; Bacterial protein of unknown function (DUF883)
      cl14813
      Location:214 → 291
      GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      101460791..101471385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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