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    Rbm11 RNA binding motif protein 11 [ Mus musculus (house mouse) ]

    Gene ID: 224344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbm11provided by MGI
    Official Full Name
    RNA binding motif protein 11provided by MGI
    Primary source
    MGI:MGI:2447622
    See related
    Ensembl:ENSMUSG00000032940 AllianceGenome:MGI:2447622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A330018F01
    Summary
    Enables poly(U) RNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within cellular response to oxidative stress. Predicted to be located in nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skeleton. Orthologous to human RBM11 (RNA binding motif protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in genital fat pad adult (RPKM 13.3), testis adult (RPKM 1.0) and 4 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbm11 in Genome Data Viewer
    Location:
    16 C3.1; 16 43.22 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (75389796..75399706)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (75592844..75602825)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene roundabout guidance receptor 2 Neighboring gene nuclear encoded tRNA isoleucine 1 (anticodon AAT) Neighboring gene STARR-seq mESC enhancer starr_41269 Neighboring gene lipase, member I Neighboring gene predicted gene, 41474 Neighboring gene predicted gene, 30162 Neighboring gene predicted gene 15553

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The RNA recognition motif protein RBM11 is a novel tissue-specific splicing regulator. Pedrotti S, et al. Nucleic Acids Res, 2012 Feb. PMID 21984414, Free PMC Article
    2. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    3. Human chromosome 21 gene expression atlas in the mouse. Reymond A, et al. Nature, 2002 Dec 5. PMID 12466854
    4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables poly(U) RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables poly(U) RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    splicing regulator RBM11
    Names
    putative RNA-binding protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417063.1 → NP_001403992.1  splicing regulator RBM11 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC166995

    2. NM_001417067.1 → NP_001403996.1  splicing regulator RBM11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166995

    3. NM_001417069.1 → NP_001403998.1  splicing regulator RBM11 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC166995

    4. NM_198302.3 → NP_938044.1  splicing regulator RBM11 isoform 1

      See identical proteins and their annotated locations for NP_938044.1

      Status: VALIDATED

      Source sequence(s)
      AC166995
      Consensus CDS
      CCDS37377.1
      UniProtKB/Swiss-Prot
      D3Z0X9, Q80YT9, Q8BYK1
      UniProtKB/TrEMBL
      H9KUZ7
      Related
      ENSMUSP00000109891.2, ENSMUST00000114253.2
      Conserved Domains (2) summary
      COG0724
      Location:5 → 139
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12593
      Location:9 → 83
      RRM_RBM11; RNA recognition motif in vertebrate RNA-binding protein 11 (RBM11)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      75389796..75399706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80YT9.1 GenPept UniProtKB/Swiss-Prot:Q80YT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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