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    Hmga1 high mobility group AT-hook 1 [ Mus musculus (house mouse) ]

    Gene ID: 15361, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hmga1provided by MGI
    Official Full Name
    high mobility group AT-hook 1provided by MGI
    Primary source
    MGI:MGI:96160
    See related
    Ensembl:ENSMUSG00000046711 AllianceGenome:MGI:96160
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hmgi; Hmgy; Hmgiy; Hmga1a; Hmga1b
    Summary
    This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
    Expression
    Ubiquitous expression in thymus adult (RPKM 119.5), liver E14.5 (RPKM 82.7) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hmga1 in Genome Data Viewer
    Location:
    17 A3.3; 17 14.5 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (27774798..27782649)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (27556574..27563672)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16005 Neighboring gene STARR-seq mESC enhancer starr_42159 Neighboring gene STARR-seq mESC enhancer starr_42160 Neighboring gene predicted gene 9703 Neighboring gene STARR-seq mESC enhancer starr_42162 Neighboring gene small integral membrane protein 29 Neighboring gene nudix hydrolase 3 Neighboring gene STARR-positive B cell enhancer ABC_E8662 Neighboring gene STARR-seq mESC enhancer starr_42166

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Hmga1 null mice are less susceptible to chemically induced skin carcinogenesis. Visone R, et al. Eur J Cancer, 2008 Jan. PMID 18155899
    2. Transgenic mice overexpressing the wild-type form of the HMGA1 gene develop mixed growth hormone/prolactin cell pituitary adenomas and natural killer cell lymphomas. Fedele M, et al. Oncogene, 2005 May 12. PMID 15735694
    3. High level expression of the HMGI (Y) gene during embryonic development. Chiappetta G, et al. Oncogene, 1996 Dec 5. PMID 8957086
    4. IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1. Chau KY, et al. Int Immunol, 2005 Mar. PMID 15710911
    5. Genomic structure and expression of the murine Hmgi(y) gene. Liu J, et al. Gene, 2000 Apr 4. PMID 10767541

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy.
      Title: HMGA1 regulates the mitochondrial apoptosis pathway in sepsis-induced cardiomyopathy.
    2. Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern to Promote Neural Impairment in MPTP Model of Parkinson's Disease.
      Title: Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern to Promote Neural Impairment in MPTP Model of Parkinson's Disease.
    3. HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
      Title: HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression.
    4. High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
      Title: High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
    5. Asymmetric expression of maternal mRNA governs first cell-fate decision.
      Title: Asymmetric expression of maternal mRNA governs first cell-fate decision.
    6. High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition.
      Title: High-mobility group AT-hook 1 promotes cardiac dysfunction in diabetic cardiomyopathy via autophagy inhibition.
    7. HMGA1-pseudogene7 transgenic mice develop B cell lymphomas.
      Title: HMGA1-pseudogene7 transgenic mice develop B cell lymphomas.
    8. Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
      Title: Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.
    9. findings highlight a novel FoxO1/HMGA1-mediated mechanism by which insulin may regulate gene expression and metabolism.
      Title: Cross-talk among HMGA1 and FoxO1 in control of nuclear insulin signaling.
    10. HMGA1 expression was closely correlated with the clinical stage, histological grade, and tumor size in breast cancer patients and breast cancer progression in transgenic MMTV-PyMT mice
      Title: HMGA1 Overexpression is Associated With the Malignant Status and Progression of Breast Cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (42)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102580

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5'-deoxyribose-5-phosphate lyase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-loop DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA binding, bending ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-(apurinic or apyrimidinic site) endonuclease activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables minor groove of adenine-thymine-rich DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables minor groove of adenine-thymine-rich DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular function activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear retinoic acid receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoic acid receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear retinoid X receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables peroxisome proliferator activated receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peroxisome proliferator activated receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural constituent of chromatin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within B cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within autophagy IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glucose homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lung morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within lymphoid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organism growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oncogene-induced cell senescence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in oncogene-induced cell senescence ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within respiratory system process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cAMP IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucagon IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to insulin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to insulin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to insulin IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within thyroid gland development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SUMO ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in male germ cell nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in senescence-associated heterochromatin focus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in senescence-associated heterochromatin focus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    high mobility group protein HMG-I/HMG-Y
    Names
    high mobility group AT-hook protein 1
    high mobility group protein A1
    high mobility group protein I

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025427.3 → NP_001020598.1  high mobility group protein HMG-I/HMG-Y isoform a

      See identical proteins and their annotated locations for NP_001020598.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
      Source sequence(s)
      AK171334, AV018894, BY270784
      Consensus CDS
      CCDS28564.1
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0
      Related
      ENSMUSP00000156173.2, ENSMUST00000232265.2

    2. NM_001039356.2 → NP_001034445.1  high mobility group protein HMG-I/HMG-Y isoform a

      See identical proteins and their annotated locations for NP_001034445.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
      Source sequence(s)
      AK171334, AV018894, BY270784, GH454882
      Consensus CDS
      CCDS28564.1
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0
      Related
      ENSMUSP00000113015.2, ENSMUST00000118599.9
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 87
      GAGA_bind; GAGA binding protein-like family

    3. NM_001166535.1 → NP_001160007.1  high mobility group protein HMG-I/HMG-Y isoform a

      See identical proteins and their annotated locations for NP_001160007.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
      Source sequence(s)
      AK171334, AV018894, BY165675, BY270784
      Consensus CDS
      CCDS28564.1
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0
      Related
      ENSMUSP00000113916.2, ENSMUST00000119486.9
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 87
      GAGA_bind; GAGA binding protein-like family

    4. NM_001166536.1 → NP_001160008.1  high mobility group protein HMG-I/HMG-Y isoform a

      See identical proteins and their annotated locations for NP_001160008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
      Source sequence(s)
      AK171334, AV018894, BY270784
      Consensus CDS
      CCDS28564.1
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0
      Related
      ENSMUSP00000155886.2, ENSMUST00000232013.2
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 87
      GAGA_bind; GAGA binding protein-like family

    5. NM_001166537.1 → NP_001160009.1  high mobility group protein HMG-I/HMG-Y isoform b

      See identical proteins and their annotated locations for NP_001160009.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
      Source sequence(s)
      AK155661, AK171334, AV018894, BM937661, CF730372
      Consensus CDS
      CCDS50044.1
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0
      Related
      ENSMUSP00000114101.2, ENSMUST00000118570.2
      Conserved Domains (1) summary
      PRK10475
      Location:31 → 75
      PRK10475; 23S rRNA pseudouridine synthase F; Provisional

    6. NM_001166539.1 → NP_001160011.1  high mobility group protein HMG-I/HMG-Y isoform b

      See identical proteins and their annotated locations for NP_001160011.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
      Source sequence(s)
      AK171334, AV018894, BY270784, GH454882
      Consensus CDS
      CCDS50044.1
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0
      Related
      ENSMUSP00000156327.2, ENSMUST00000231825.2
      Conserved Domains (1) summary
      PRK10475
      Location:31 → 75
      PRK10475; 23S rRNA pseudouridine synthase F; Provisional

    7. NM_001166540.1 → NP_001160012.1  high mobility group protein HMG-I/HMG-Y isoform b

      See identical proteins and their annotated locations for NP_001160012.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
      Source sequence(s)
      AK155661, AK171334, AV018894, BY165675, BY270784
      Consensus CDS
      CCDS50044.1
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0
      Related
      ENSMUSP00000156044.2, ENSMUST00000232552.2
      Conserved Domains (1) summary
      PRK10475
      Location:31 → 75
      PRK10475; 23S rRNA pseudouridine synthase F; Provisional

    8. NM_001166541.1 → NP_001160013.1  high mobility group protein HMG-I/HMG-Y isoform b

      See identical proteins and their annotated locations for NP_001160013.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
      Source sequence(s)
      AK155661, AK171334, AV018894, BY270784
      Consensus CDS
      CCDS50044.1
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0
      Related
      ENSMUSP00000110538.4, ENSMUST00000114888.11
      Conserved Domains (1) summary
      PRK10475
      Location:31 → 75
      PRK10475; 23S rRNA pseudouridine synthase F; Provisional

    9. NM_001166542.1 → NP_001160014.1  high mobility group protein HMG-I/HMG-Y isoform b

      See identical proteins and their annotated locations for NP_001160014.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (b) is shorter than isoform a. Variants 6 through 10 encode the same isoform (b), also known as isoform Y.
      Source sequence(s)
      AK155661, AK171334, AV018894, BY270784
      Consensus CDS
      CCDS50044.1
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0
      Related
      ENSMUSP00000155876.2, ENSMUST00000231358.2
      Conserved Domains (1) summary
      PRK10475
      Location:31 → 75
      PRK10475; 23S rRNA pseudouridine synthase F; Provisional

    10. NM_001166543.1 → NP_001160015.1  high mobility group protein HMG-I/HMG-Y isoform c

      See identical proteins and their annotated locations for NP_001160015.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
      Source sequence(s)
      AK171334, AV018894, BY165675, BY270784
      Consensus CDS
      CCDS89033.1
      UniProtKB/TrEMBL
      Q3TE85
      Related
      ENSMUSP00000155874.2, ENSMUST00000232253.2
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 101
      GAGA_bind; GAGA binding protein-like family

    11. NM_001166544.1 → NP_001160016.1  high mobility group protein HMG-I/HMG-Y isoform c

      See identical proteins and their annotated locations for NP_001160016.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and uses an alternate, in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a. Variants 11 and 12 encode the same isoform (c).
      Source sequence(s)
      AK171334, AV018894, BY270784
      Consensus CDS
      CCDS89033.1
      UniProtKB/TrEMBL
      Q3TE85
      Related
      ENSMUSP00000113068.3, ENSMUST00000117600.9
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 101
      GAGA_bind; GAGA binding protein-like family

    12. NM_001166545.1 → NP_001160017.1  high mobility group protein HMG-I/HMG-Y isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and uses an alternate, in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (d) is longer than isoform a.
      Source sequence(s)
      AK171334, AV018894, BY270784, CF951929
      Consensus CDS
      CCDS89032.1
      UniProtKB/TrEMBL
      A0A338P6E8
      Related
      ENSMUSP00000155922.2, ENSMUST00000231796.2

    13. NM_001166546.1 → NP_001160018.1  high mobility group protein HMG-I/HMG-Y isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform e, which has a longer and distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AK171334, AV018894, BY270784
      Consensus CDS
      CCDS89034.1
      UniProtKB/TrEMBL
      A0A338P6F6
      Related
      ENSMUSP00000155966.2, ENSMUST00000231866.2

    14. NM_001412718.1 → NP_001399647.1  high mobility group protein HMG-I/HMG-Y isoform b

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0

    15. NM_001412721.1 → NP_001399650.1  high mobility group protein HMG-I/HMG-Y isoform f

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6D0

    16. NM_001412722.1 → NP_001399651.1  high mobility group protein HMG-I/HMG-Y isoform f

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6D0

    17. NM_001412723.1 → NP_001399652.1  high mobility group protein HMG-I/HMG-Y isoform e

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6F6

    18. NM_001412724.1 → NP_001399653.1  high mobility group protein HMG-I/HMG-Y isoform e

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6F6

    19. NM_001412726.1 → NP_001399655.1  high mobility group protein HMG-I/HMG-Y isoform f

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6D0

    20. NM_001412727.1 → NP_001399656.1  high mobility group protein HMG-I/HMG-Y isoform e

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6F6

    21. NM_001412728.1 → NP_001399657.1  high mobility group protein HMG-I/HMG-Y isoform f

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6D0
      Related
      ENSMUSP00000155919.2, ENSMUST00000231243.2

    22. NM_001412729.1 → NP_001399658.1  high mobility group protein HMG-I/HMG-Y isoform d

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6E8

    23. NM_001412730.1 → NP_001399659.1  high mobility group protein HMG-I/HMG-Y isoform d

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6E8

    24. NM_001412731.1 → NP_001399660.1  high mobility group protein HMG-I/HMG-Y isoform a

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0

    25. NM_001412732.1 → NP_001399661.1  high mobility group protein HMG-I/HMG-Y isoform a

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0

    26. NM_001412733.1 → NP_001399662.1  high mobility group protein HMG-I/HMG-Y isoform a

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0

    27. NM_001412740.1 → NP_001399669.1  high mobility group protein HMG-I/HMG-Y isoform a

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0

    28. NM_001412748.1 → NP_001399677.1  high mobility group protein HMG-I/HMG-Y isoform g

      Status: REVIEWED

      Source sequence(s)
      AC127341

    29. NM_001412749.1 → NP_001399678.1  high mobility group protein HMG-I/HMG-Y isoform g

      Status: REVIEWED

      Source sequence(s)
      AC127341

    30. NM_001412750.1 → NP_001399679.1  high mobility group protein HMG-I/HMG-Y isoform h

      Status: REVIEWED

      Source sequence(s)
      AC127341

    31. NM_001412751.1 → NP_001399680.1  high mobility group protein HMG-I/HMG-Y isoform g

      Status: REVIEWED

      Source sequence(s)
      AC127341

    32. NM_001412752.1 → NP_001399681.1  high mobility group protein HMG-I/HMG-Y isoform g

      Status: REVIEWED

      Source sequence(s)
      AC127341

    33. NM_001412754.1 → NP_001399683.1  high mobility group protein HMG-I/HMG-Y isoform h

      Status: REVIEWED

      Source sequence(s)
      AC127341

    34. NM_001412755.1 → NP_001399684.1  high mobility group protein HMG-I/HMG-Y isoform h

      Status: REVIEWED

      Source sequence(s)
      AC127341

    35. NM_001412764.1 → NP_001399693.1  high mobility group protein HMG-I/HMG-Y isoform h

      Status: REVIEWED

      Source sequence(s)
      AC127341

    36. NM_001412765.1 → NP_001399694.1  high mobility group protein HMG-I/HMG-Y isoform g

      Status: REVIEWED

      Source sequence(s)
      AC127341

    37. NM_001412766.1 → NP_001399695.1  high mobility group protein HMG-I/HMG-Y isoform c

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      Q3TE85

    38. NM_001412767.1 → NP_001399696.1  high mobility group protein HMG-I/HMG-Y isoform c

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      Q3TE85

    39. NM_001412768.1 → NP_001399697.1  high mobility group protein HMG-I/HMG-Y isoform c

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      Q3TE85

    40. NM_001412769.1 → NP_001399698.1  high mobility group protein HMG-I/HMG-Y isoform c

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      Q3TE85

    41. NM_001412770.1 → NP_001399699.1  high mobility group protein HMG-I/HMG-Y isoform i

      Status: REVIEWED

      Source sequence(s)
      AC127341

    42. NM_001412771.1 → NP_001399700.1  high mobility group protein HMG-I/HMG-Y isoform i

      Status: REVIEWED

      Source sequence(s)
      AC127341

    43. NM_001412772.1 → NP_001399701.1  high mobility group protein HMG-I/HMG-Y isoform i

      Status: REVIEWED

      Source sequence(s)
      AC127341

    44. NM_001412773.1 → NP_001399702.1  high mobility group protein HMG-I/HMG-Y isoform i

      Status: REVIEWED

      Source sequence(s)
      AC127341

    45. NM_001412783.1 → NP_001399712.1  high mobility group protein HMG-I/HMG-Y isoform b

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0

    46. NM_001412943.1 → NP_001399872.1  high mobility group protein HMG-I/HMG-Y isoform j

      Status: REVIEWED

      Source sequence(s)
      AC127341

    47. NM_001412944.1 → NP_001399873.1  high mobility group protein HMG-I/HMG-Y isoform j

      Status: REVIEWED

      Source sequence(s)
      AC127341

    48. NM_001412945.1 → NP_001399874.1  high mobility group protein HMG-I/HMG-Y isoform j

      Status: REVIEWED

      Source sequence(s)
      AC127341

    49. NM_001412949.1 → NP_001399878.1  high mobility group protein HMG-I/HMG-Y isoform b

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0

    50. NM_001412950.1 → NP_001399879.1  high mobility group protein HMG-I/HMG-Y isoform b

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, Q3TVP0

    51. NM_001412951.1 → NP_001399880.1  high mobility group protein HMG-I/HMG-Y isoform k

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, A0A384DV79

    52. NM_001412952.1 → NP_001399881.1  high mobility group protein HMG-I/HMG-Y isoform k

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, A0A384DV79
      Related
      ENSMUSP00000113011.3, ENSMUST00000117254.9

    53. NM_001412953.1 → NP_001399882.1  high mobility group protein HMG-I/HMG-Y isoform k

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6, A0A384DV79

    54. NM_001412954.1 → NP_001399883.1  high mobility group protein HMG-I/HMG-Y isoform L

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6

    55. NM_001412955.1 → NP_001399884.1  high mobility group protein HMG-I/HMG-Y isoform m

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6

    56. NM_001412956.1 → NP_001399885.1  high mobility group protein HMG-I/HMG-Y isoform m

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6

    57. NM_001412957.1 → NP_001399886.1  high mobility group protein HMG-I/HMG-Y isoform m

      Status: REVIEWED

      Source sequence(s)
      AC127341
      UniProtKB/TrEMBL
      A0A338P6G6

    58. NM_001412958.1 → NP_001399887.1  high mobility group protein HMG-I/HMG-Y isoform n

      Status: REVIEWED

      Source sequence(s)
      AC127341

    59. NM_001412959.1 → NP_001399888.1  high mobility group protein HMG-I/HMG-Y isoform n

      Status: REVIEWED

      Source sequence(s)
      AC127341

    60. NM_001413142.1 → NP_001400071.1  high mobility group protein HMG-I/HMG-Y isoform r

      Status: REVIEWED

      Source sequence(s)
      AC127341

    61. NM_001413143.1 → NP_001400072.1  high mobility group protein HMG-I/HMG-Y isoform q

      Status: REVIEWED

      Source sequence(s)
      AC127341

    62. NM_001413144.1 → NP_001400073.1  high mobility group protein HMG-I/HMG-Y isoform p

      Status: REVIEWED

      Source sequence(s)
      AC127341

    63. NM_016660.3 → NP_057869.2  high mobility group protein HMG-I/HMG-Y isoform a

      See identical proteins and their annotated locations for NP_057869.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1 through 5 encode the same isoform (a), also known as isoform I.
      Source sequence(s)
      AK171334, AV018894, BM937661, CF730372
      Consensus CDS
      CCDS28564.1
      UniProtKB/Swiss-Prot
      P17095, Q91WV2, Q924L7, Q924L8
      UniProtKB/TrEMBL
      Q566K0
      Related
      ENSMUSP00000156199.2, ENSMUST00000231874.2
      Conserved Domains (1) summary
      pfam06217
      Location:4 → 87
      GAGA_bind; GAGA binding protein-like family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      27774798..27782649
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17095.4 GenPept UniProtKB/Swiss-Prot:P17095

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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