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    Srd5a2 steroid 5 alpha-reductase 2 [ Mus musculus (house mouse) ]

    Gene ID: 94224, updated on 27-Nov-2024

    Summary

    Official Symbol
    Srd5a2provided by MGI
    Official Full Name
    steroid 5 alpha-reductase 2provided by MGI
    Primary source
    MGI:MGI:2150380
    See related
    Ensembl:ENSMUSG00000038541 AllianceGenome:MGI:2150380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5ART2; S5AR 2
    Summary
    Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Involved in androgen biosynthetic process. Acts upstream of or within male genitalia development and steroid biosynthetic process. Predicted to be located in cell body fiber and neuronal cell body. Predicted to be active in endoplasmic reticulum membrane. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 248.6) See more
    Orthologs
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    Genomic context

    See Srd5a2 in Genome Data Viewer
    Location:
    17 E2; 17 45.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74321886..74354855, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74014891..74047860, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30983 Neighboring gene predicted gene, 24475 Neighboring gene STARR-seq mESC enhancer starr_43206 Neighboring gene predicted gene, 31235 Neighboring gene STARR-seq mESC enhancer starr_43207 Neighboring gene STARR-seq mESC enhancer starr_43208 Neighboring gene STARR-positive B cell enhancer ABC_E9171 Neighboring gene predicted gene, 53978

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-oxo-5alpha-steroid 4-dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables amide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables testosterone dehydrogenase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables testosterone dehydrogenase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within androgen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in androgen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in biphenyl metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in dibenzo-p-dioxin metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female genitalia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hypothalamus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male gonad development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in male gonad development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in phthalate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to biphenyl IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to biphenyl ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to follicle-stimulating hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to steroid hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within steroid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in testosterone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in testosterone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell body fiber IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    3-oxo-5-alpha-steroid 4-dehydrogenase 2
    Names
    5 alpha-SR2
    SR type 2
    steroid 5 alpha reductase type2
    NP_444418.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053188.3NP_444418.1  3-oxo-5-alpha-steroid 4-dehydrogenase 2

      See identical proteins and their annotated locations for NP_444418.1

      Status: VALIDATED

      Source sequence(s)
      CT025731
      Consensus CDS
      CCDS28968.1
      UniProtKB/Swiss-Prot
      Q3UTZ9, Q99N99
      Related
      ENSMUSP00000048862.8, ENSMUST00000043458.9
      Conserved Domains (1) summary
      pfam02544
      Location:105254
      Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      74321886..74354855 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)