Depdc1a DEP domain containing 1a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Depdc1aprovided by MGI
Official Full Name: DEP domain containing 1aprovided by MGI
Primary source: MGI:MGI:1923381
See related: Ensembl:ENSMUSG00000028175 AllianceGenome:MGI:1923381
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Depdc1; 5830484J08Rik
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. Orthologous to human DEPDC1 (DEP domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver E14 (RPKM 10.2), liver E14.5 (RPKM 7.6) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 H4; 3 82.47 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (159201042..159235690)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (159495414..159529955)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription repressor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription repressor complex	ISO Inferred from Sequence Orthology more info
part_of transcription repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: DEP domain-containing protein 1A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172092.1 → NP_001165563.1 DEP domain-containing protein 1A isoform 1

See identical proteins and their annotated locations for NP_001165563.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK050456, AK146458, BB857645, CK340717

Consensus CDS

CCDS51105.1

UniProtKB/TrEMBL

A0A2X0SSJ1, D3Z6J1

Related

ENSMUSP00000113216.2, ENSMUST00000120272.8

Conserved Domains (3) summary

cd04405
Location:182 → 309

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cl02442
Location:15 → 106

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

cl02570
Location:576 → 684

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001172093.1 → NP_001165564.1 DEP domain-containing protein 1A isoform 3

See identical proteins and their annotated locations for NP_001165564.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1.

Source sequence(s)

AK050456, AK146458, BB857645, CK340717

Consensus CDS

CCDS51106.1

UniProtKB/Swiss-Prot

Q8CIG0

Related

ENSMUSP00000101656.3, ENSMUST00000106041.3

Conserved Domains (2) summary

cd04405
Location:182 → 407

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cl02442
Location:15 → 106

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...
NM_029523.3 → NP_083799.2 DEP domain-containing protein 1A isoform 2

See identical proteins and their annotated locations for NP_083799.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks a two amino acid segment near the C-terminus, compared to isoform 1.

Source sequence(s)

AK050456, AK146458, BB857645, CK340717

Consensus CDS

CCDS17936.1

UniProtKB/Swiss-Prot

Q8BHF1, Q8CIG0, Q99JN3

UniProtKB/TrEMBL

A0A2X0SSJ1

Related

ENSMUSP00000029825.8, ENSMUST00000029825.14

Conserved Domains (3) summary

cd04405
Location:182 → 309

RhoGAP_BRCC3-like; RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain ...

cl02442
Location:15 → 106

DEP; DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is ...

cl02570
Location:576 → 684

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...