Sec11a SEC11 homolog A, signal peptidase complex subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sec11aprovided by MGI
Official Full Name: SEC11 homolog A, signal peptidase complex subunitprovided by MGI
Primary source: MGI:MGI:1929464
See related: Ensembl:ENSMUSG00000025724 AllianceGenome:MGI:1929464
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 18kDa; Spc18; Sec11l1; sid2895; Sid2895p; 1810012E07Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Is expressed in several structures, including alimentary system; cranium; genitourinary system; integumental system; and nervous system. Orthologous to human SEC11A (SEC11 homolog A, signal peptidase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 78.7), limb E14.5 (RPKM 45.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 D3; 7 45.71 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (80565125..80597295, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (80915379..80947550, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH129975 (e-PCR)
- UniSTS:213263

38.MMHAP97FRE11.seq (e-PCR)
- UniSTS:124305

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info
involved_in signal peptide processing	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: signal peptidase complex catalytic subunit SEC11A

Names: SEC11-like protein 1; SPase 18 kDa subunit; Sec11-like 1; endopeptidase SP18; microsomal signal peptidase 18 kDa subunit; sid 2895; signal peptidase complex (18kD)

NP_001405484.1

EC 3.4.21.89

NP_001405485.1

EC 3.4.21.89

NP_001405486.1

EC 3.4.21.89

NP_001405487.1

EC 3.4.21.89

NP_001405488.1

EC 3.4.21.89

NP_064335.1

EC 3.4.21.89

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418555.1 → NP_001405484.1 signal peptidase complex catalytic subunit SEC11A isoform 2

Status: VALIDATED

Source sequence(s)

AC123744
NM_001418556.1 → NP_001405485.1 signal peptidase complex catalytic subunit SEC11A isoform 3

Status: VALIDATED

Source sequence(s)

AC123744

UniProtKB/TrEMBL

D3YWT0, D3Z569

Related

ENSMUSP00000113601.2, ENSMUST00000117383.8
NM_001418557.1 → NP_001405486.1 signal peptidase complex catalytic subunit SEC11A isoform 4

Status: VALIDATED

Source sequence(s)

AC123744
NM_001418558.1 → NP_001405487.1 signal peptidase complex catalytic subunit SEC11A isoform 5

Status: VALIDATED

Source sequence(s)

AC123744

UniProtKB/TrEMBL

D3YWT0
NM_001418559.1 → NP_001405488.1 signal peptidase complex catalytic subunit SEC11A isoform 6

Status: VALIDATED

Source sequence(s)

AC123744
NM_019951.2 → NP_064335.1 signal peptidase complex catalytic subunit SEC11A isoform 1

See identical proteins and their annotated locations for NP_064335.1

Status: VALIDATED

Source sequence(s)

AC123744

Consensus CDS

CCDS21401.1

UniProtKB/Swiss-Prot

Q9R0P6

UniProtKB/TrEMBL

D3YWT0

Related

ENSMUSP00000026818.6, ENSMUST00000026818.12

Conserved Domains (1) summary

cl10465
Location:38 → 150

Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...