ura1 bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: ura1
Official Full Name: bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1
Primary source: PomBase:SPAC22G7.06c
Locus tag: SPOM_SPAC22G7.06C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Genomic context

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See ura1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (739167..746114, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GMP synthase (glutamine-hydrolyzing) activity	IGI Inferred from Genetic Interaction more info	PubMed
enables amino acid binding	IEA Inferred from Electronic Annotation more info
enables aspartate carbamoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aspartate carbamoyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables aspartate carbamoyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables carbamoyl-phosphate synthase (ammonia) activity	IEA Inferred from Electronic Annotation more info
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity	IGI Inferred from Genetic Interaction more info	PubMed
NOT enables dihydroorotase activity	EXP Inferred from Experiment more info	PubMed
enables glutaminase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' UMP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' pyrimidine nucleobase biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glutamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamine metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

739167..746114 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001018453.3 → NP_593055.1 bifunctional carbamoyl-phosphate synthase/aspartate carbamoyltransferase Ura1 [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_593055.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

Q09794

Conserved Domains (12) summary

cd01744
Location:265 → 440

GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II

COG0505
Location:57 → 449

CarA; Carbamoylphosphate synthase small subunit [Amino acid transport and metabolism, Nucleotide transport and metabolism]

COG0540
Location:1931 → 2242

PyrB; Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]

cd01316
Location:1535 → 1862

CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...

cd01423
Location:1395 → 1515

MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.

TIGR01369
Location:473 → 1517

CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit

pfam00185
Location:2085 → 2234

OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain

pfam00988
Location:61 → 197

CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain

pfam02729
Location:1938 → 2078

OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain

pfam02786
Location:593 → 795

CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

pfam02787
Location:882 → 1002

CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain

cl17255
Location:1151 → 1328

ATP-grasp_4; ATP-grasp domain