taz1 telomere length regulator [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

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Official Symbol: taz1
Official Full Name: telomere length regulator
Primary source: PomBase:SPAC16A10.07c
Locus tag: SPOM_SPAC16A10.07C
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
Also known as: lot3; myb; myb1
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Genomic context

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See taz1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 1

Sequence:: Chromosome: I; NC_003424.3 (3091021..3093260, complement)

Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003424.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
Title: The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
Fission yeast cells lacking shelterin components Taz1 or Rap1 showed higher gross chromosomal rearrangements (GCRs) rates compared to wild-type, accumulating large chromosome deletions. Study results highlight unappreciated functions of the shelterin components Taz1 and Rap1 in maintaining genome stability, specifically by preventing non-telomeric GCRs.
Title: Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast.
Telosome formation depends on the conserved telomeric proteins Taz1 and Rap1, and RNA. The lack of a detectable telosome in the absence of Taz1 indicates that Taz1 is required for telosome formation or integrity. Taz1 and Rap1 act together in organizing the telosome.
Title: Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA.
The results suggest that Taz1 suppresses replication initiation through shelterin-mediated telomeric association of the origins at the onset of S phase.
Title: Shelterin promotes tethering of late replication origins to telomeres for replication-timing control.
Genetic screens for identifying cis- and trans-acting factors creating heterochromatin-euchromatin boundaries showed unexpected properties for Rif1 and Taz1. Most cis-acting elements identified came from genomic loci bound by Taz1 and associated with origins of replication repressed by Taz1 and Rif1. Boundary formation by these elements required Taz1 and Rif1 and coincided with altered replication timing.
Title: Establishment of expression-state boundaries by Rif1 and Taz1 in fission yeast.
Taz1-Shelterin promotes facultative heterochromatin assembly at chromosome-internal sites containing late replication origins.
Title: Taz1-Shelterin Promotes Facultative Heterochromatin Assembly at Chromosome-Internal Sites Containing Late Replication Origins.
Centromere detachment required telomere clustering-dependent spindle pole body recruitment of Taz1 and microtubules.
Title: A Taz1- and Microtubule-Dependent Regulatory Relationship between Telomere and Centromere Positions in Bouquet Formation Secures Proper Meiotic Divisions.
Data indicate the differences in requirements of DNA-binding protein Teb1p and telomere-binding protein Taz1p for DNA binding
Title: Evolution of Telomeres in Schizosaccharomyces pombe and Its Possible Relationship to the Diversification of Telomere Binding Proteins.
telomere-binding protein Taz1 plays a crucial role in the control of replication timing in fission yeast
Title: Telomere-binding protein Taz1 controls global replication timing through its localization near late replication origins in fission yeast.
Taz1 is required for cell-cycle restriction of telomerase activity
Title: Taz1 enforces cell-cycle regulation of telomere synthesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by PomBase

Function	Evidence Code	Pubs
enables double-stranded telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables telomeric DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in meiotic attachment of telomere to nuclear envelope	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic attachment of telomeric heterochromatin to spindle pole body	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic telomere tethering at nuclear periphery	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protection from non-homologous end joining at telomere	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere capping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in telomere maintenance	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in chromosome, telomeric repeat region	IDA Inferred from Direct Assay more info	PubMed
is_active_in meiotic spindle pole body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	EXP Inferred from Experiment more info	PubMed
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus leading edge	IDA Inferred from Direct Assay more info	PubMed
part_of shelterin complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: telomere length regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003424.3 Reference assembly

Range

3091021..3093260 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001019472.3 → NP_594047.1 telomere length regulator [Schizosaccharomyces pombe]

See identical proteins and their annotated locations for NP_594047.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O00049, P79005

Conserved Domains (5) summary

smart00717
Location:558 → 612

SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

cd11654
Location:452 → 496

TRF2_RBM; RAP1 binding motif of telomere repeat binding factor

cd11660
Location:559 → 610

SANT_TRF; Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family

cd11671
Location:361 → 394

TAZ1_RBM; RAP1 binding motif of Schizosaccharomyces pombe TAZ1

cl02779
Location:124 → 351

TRFH; Telomeric Repeat binding Factor or TTAGGG Repeat binding Factor, central (dimerization) domain Homology; TRFH. Telomeres are protein/DNA complexes that make up the physical ends of eukaryotic linear chromosomes and are essential for chromosome stability, ...