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    tsn1 translin [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541714, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tsn1
    Official Full Name
    translin
    Primary source
    PomBase:SPAC30.03c
    Locus tag
    SPOM_SPAC30.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug90; tsn
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    Genomic context

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    See tsn1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003424.3 (4394376..4395629, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Sec7 domain-containing protein sec72 Neighboring gene ncRNA Neighboring gene elongator complex-associated protein Kti2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene vacuolar phytochelatin and glutathione S-conjugate ABC family transmembrane transporter Abc4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study. Eliahoo E, et al. Nucleic Acids Res, 2010 May. PMID 20081200, Free PMC Article
    2. Functional characterisation of the Schizosaccharomyces pombe homologue of the leukaemia-associated translocation breakpoint binding protein translin and its binding partner, TRAX. Jaendling A, et al. Biochim Biophys Acta, 2008 Feb. PMID 18062930
    3. Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX. Laufman O, et al. Nucleic Acids Res, 2005. PMID 16043634, Free PMC Article
    4. Biochemical characterization of clinically relevant mutations of human Translin. Pillai V, et al. Mol Cell Biochem, 2023 Apr. PMID 36098897
    5. Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe. Eliahoo E, et al. Biochim Biophys Acta, 2014 Apr. PMID 24382491

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Translin and Trax differentially regulate telomere-associated transcript homeostasis.
      Title: Translin and Trax differentially regulate telomere-associated transcript homeostasis.
    2. Translin binds the pre-mRNA-splicing factor srp1 and vip1, a protein conserved in fungi.
      Title: Identification of proteins that form specific complexes with the highly conserved protein Translin in Schizosaccharomyces pombe.
    3. Bioinformatics combined with yeast two-hybrid assays and proteomic analyses of deletion variants, identified at the top of the spTranslin structure a region required for interaction with spTRAX, and for spTranslin dimerization.
      Title: Mapping of interaction sites of the Schizosaccharomyces pombe protein Translin with nucleic acids and proteins: a combined molecular genetics and bioinformatics study.
    4. Translin is a non-essential, octameric protein that selectively binds ssDNA microsatellite repeats & corresponding RNA sequences but not dsDNA. Its much higher affinity for RNA repeats suggests that it's involved in RNA metabolism-related functions. [tsn]
      Title: Cloning and characterization of the Schizosaccharomyces pombe homologs of the human protein Translin and the Translin-associated protein TRAX.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables GU repeat RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to RNA nuclease activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microsatellite binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded telomeric DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT involved_in double-strand break repair via nonhomologous end joining TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    translin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4394376..4395629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019986.4 → NP_594557.2  translin [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594557.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7V3
      Conserved Domains (1) summary
      cd14819
      Location:9 → 218
      Translin; Translin, also known as TB-RBP (testis brain RNA-binding protein)
    Nucleotide Protein
    Heading Accession and Version

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