U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pli1 SUMO E3 ligase Pli1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541580, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pli1
    Official Full Name
    SUMO E3 ligase Pli1
    Primary source
    PomBase:SPAC1687.05
    Locus tag
    SPOM_SPAC1687.05
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pli1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003424.3 (908696..911854)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mini-chromosome maintenance complex-binding protein mcb1 Neighboring gene ncRNA Neighboring gene ribosomal L28e protein family domain-containing protein Neighboring gene 5S ribosomal RNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. SUMOylation regulates Lem2 function in centromere clustering and silencing. Strachan J, et al. J Cell Sci, 2023 Dec 1. PMID 37970674, Free PMC Article
    2. Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance. Xhemalce B, et al. EMBO J, 2004 Oct 1. PMID 15359282, Free PMC Article
    3. Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability. Steinacher R, et al. PLoS One, 2013. PMID 23936535, Free PMC Article
    4. Pli1(PIAS1) SUMO ligase protected by the nuclear pore-associated SUMO protease Ulp1SENP1/2. Nie M, et al. J Biol Chem, 2015 Sep 11. PMID 26221037, Free PMC Article
    5. The role of Schizosaccharomyces pombe SUMO ligases in genome stability. Watts FZ, et al. Biochem Soc Trans, 2007 Dec. PMID 18031226

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SUMOylation and SUMO-dependent ubiquitylation by the Pli1-Slx8 axis contribute in different ways to maintain genome stability
      Title: Slx8 removes Pli1-dependent protein-SUMO conjugates including SUMOylated topoisomerase I to promote genome stability.
    2. study identifies the existence of an additional DNA interstrand cross-link (ICL) resolution pathway dependent on the SUMO E3 ligase Pli1
      Title: The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables SUMO ligase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables SUMO ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centromere clustering at the mitotic interphase nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in linear element assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in non-recombinational interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in stalled replication fork localization to nuclear periphery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    SUMO E3 ligase Pli1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      908696..911854
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018519.3 → NP_593123.1  SUMO E3 ligase Pli1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593123.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94451
      Conserved Domains (3) summary
      pfam02037
      Location:21 → 52
      SAP; SAP domain
      pfam02891
      Location:301 → 347
      zf-MIZ; MIZ/SP-RING zinc finger
      pfam14324
      Location:119 → 251
      PINIT; PINIT domain
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Miscellaneous