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    hmg1 3-hydroxy-3-methylglutaryl-CoA reductase Hmg1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538999, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hmg1
    Official Full Name
    3-hydroxy-3-methylglutaryl-CoA reductase Hmg1
    Primary source
    PomBase:SPCC162.09c
    Locus tag
    SPOM_SPCC162.09C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    its12
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    Genomic context

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    See hmg1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1561215..1565491)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uridine kinase/uracil phosphoribosyltransferase Neighboring gene ncRNA Neighboring gene serine/threonine protein kinase Ppk33 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene nucleoporin nup211 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Design, synthesis, and docking of highly hypolipidemic agents: Schizosaccharomyces pombe as a new model for evaluating alpha-asarone-based HMG-CoA reductase inhibitors. Argüelles N, et al. Bioorg Med Chem, 2010 Jun 15. PMID 20576575
    2. Isolation of a fission yeast mutant cell affected in MAP kinase signaling and sterol biosynthesis. Imagawa K, et al. Kobe J Med Sci, 2009 Jun 5. PMID 20847589
    3. Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast. Burg JS, et al. Cell Metab, 2008 Dec. PMID 19041767, Free PMC Article
    4. Glucose controls phosphoregulation of hydroxymethylglutaryl coenzyme A reductase through the protein phosphatase 2A-related phosphatase protein, Ppe1, and Insig in fission yeast. Burg JS, et al. J Biol Chem, 2011 Aug 5. PMID 21680738, Free PMC Article
    5. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, et al. EMBO J, 2005 Nov 16. PMID 16270032, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This is the first demonstration of clear phenotypes arising from a nonsense mutation of an essential gene, HMG1, in fission yeast.
      Title: Pleiotropic phenotypes caused by an opal nonsense mutation in an essential gene encoding HMG-CoA reductase in fission yeast.
    2. Intracellular Signaling Peptides and Proteins dependent regulation of 3-hydroxy-3-methylglutaryl-CoA reductase activity functions through the phosphorylation of S1024 and T1028.
      Title: Insig regulates HMG-CoA reductase by controlling enzyme phosphorylation in fission yeast.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxymethylglutaryl-CoA reductase (NADPH) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sterol sensor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in isopentenyl diphosphate biosynthetic process, mevalonate pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    3-hydroxy-3-methylglutaryl-CoA reductase Hmg1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1561215..1565491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023225.3 → NP_588235.1  3-hydroxy-3-methylglutaryl-CoA reductase Hmg1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588235.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74425, Q10283
      Conserved Domains (3) summary
      cd00643
      Location:617 → 1023
      HMG-CoA_reductase_classI; Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR)
      pfam13323
      Location:4 → 30
      HPIH; N-terminal domain with HPIH motif
      cl21543
      Location:231 → 371
      MMPL; MMPL family
    Nucleotide Protein
    Heading Accession and Version

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