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    lys12 homoisocitrate dehydrogenase Lys12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542609, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lys12
    Official Full Name
    homoisocitrate dehydrogenase Lys12
    Primary source
    PomBase:SPAC31G5.04
    Locus tag
    SPOM_SPAC31G5.04
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See lys12 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (2993442..2994929)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene chaperone Rot1 Neighboring gene ncRNA Neighboring gene 40S ribosomal protein uS17 Neighboring gene ribulose phosphate 3-epimerase Neighboring gene ncRNA Neighboring gene protein Rgg8 Neighboring gene tetraspan protein, claudin Dni1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe. Bulfer SL, et al. Proteins, 2012 Feb. PMID 22105743, Free PMC Article
    2. Global fitness profiling of fission yeast deletion strains by barcode sequencing. Han TX, et al. Genome Biol, 2010. PMID 20537132, Free PMC Article
    3. Six new amino acid-auxotrophic markers for targeted gene integration and disruption in fission yeast. Ma Y, et al. Curr Genet, 2007 Aug. PMID 17622533
    4. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    5. A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response. Ptushkina M, et al. Sci Rep, 2017 Sep 21. PMID 28935859, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of homoisocitrate dehydrogenase and its active site
      Title: Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homoisocitrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lysine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lysine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lysine biosynthetic process via aminoadipic acid IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in mitochondrial matrix IC
    Inferred by Curator
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homoisocitrate dehydrogenase Lys12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2993442..2994929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019430.3 → NP_594004.1  homoisocitrate dehydrogenase Lys12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594004.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14104
      Conserved Domains (1) summary
      COG0473
      Location:2 → 362
      LeuB; Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version

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