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    putative phosphotransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851687, updated on 9-Dec-2024

    Summary

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    Official Full Name
    putative phosphotransferase
    Primary source
    SGD:S000002516
    Locus tag
    YDR109C
    See related
    AllianceGenome:SGD:S000002516; FungiDB:YDR109C; VEuPathDB:YDR109C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables D-ribulokinase activity. Involved in pentose metabolic process. Predicted to be active in cytoplasm. Orthologous to human FGGY (FGGY carbohydrate kinase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (673520..675667, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Tmn2p Neighboring gene Trs85p Neighboring gene replication fork barrier binding protein FOB1 Neighboring gene alanine transaminase ALT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular Identification of d-Ribulokinase in Budding Yeast and Mammals. Singh C, et al. J Biol Chem, 2017 Jan 20. PMID 27909055, Free PMC Article
    2. The COG database: a tool for genome-scale analysis of protein functions and evolution. Tatusov RL, et al. Nucleic Acids Res, 2000 Jan 1. PMID 10592175, Free PMC Article
    3. The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Jacq C, et al. Nature, 1997 May 29. PMID 9169867
    4. Interrogation of γ-tubulin alleles using high-resolution fitness measurements reveals a distinct cytoplasmic function in spindle alignment. Shulist K, et al. Sci Rep, 2017 Sep 12. PMID 28900268, Free PMC Article
    5. Global analysis of protein phosphorylation in yeast. Ptacek J, et al. Nature, 2005 Dec 1. PMID 16319894

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables D-ribulokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-ribulokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-ribulokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pentose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pentose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in pentose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative phosphotransferase
    NP_010394.3
    • D-ribulokinase; carbohydrate kinase that specifically converts D-ribulose to D-ribulose 5-phosphate during pentose metabolism; null mutant accumulates D-ribulose and the precursor ribitol; proposed to function as a D-ribulose metabolic repair enzyme; member of the FGGY family of carbohydrate kinases; human homolog, FGGY, is involved in both D-ribulose and ribitol metabolism; human FGGY has been linked to both sporadic amyotrophic lateral sclerosis and bipolar disorder

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      673520..675667 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180417.3 → NP_010394.3  TPA: putative phosphotransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010394.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS95, Q04585
      UniProtKB/TrEMBL
      B3LGG6, C8Z525
      Conserved Domains (1) summary
      cd07782
      Location:38 → 703
      FGGY_YpCarbK_like; Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04585.1

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