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    gad8 serine/threonine protein kinase (AGC family) Gad8 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539206, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gad8
    Official Full Name
    serine/threonine protein kinase (AGC family) Gad8
    Primary source
    PomBase:SPCC24B10.07
    Locus tag
    SPOM_SPCC24B10.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gad8 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (912500..915238)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Tim9-Tim10 complex subunit Tim9 Neighboring gene ncRNA Neighboring gene SAGA complex subunit Ada2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 40S ribosomal protein eS17

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast. Pataki E, et al. PLoS Genet, 2020 Nov. PMID 33137119, Free PMC Article
    2. TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium. Baker K, et al. Elife, 2019 Sep 30. PMID 31566560, Free PMC Article
    3. Phosphorylation of Wat1, human Lst8 homolog is critical for the regulation of TORC2 -Gad8 dependent pathway in fission yeast Schizosacchromyces pombe. Ahamad N, et al. Eur J Cell Biol, 2018 May. PMID 29699848
    4. Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition. Hálová L, et al. J Cell Biol, 2013 Nov 25. PMID 24247430, Free PMC Article
    5. Schizosaccharomyces pombe AGC family kinase Gad8p forms a conserved signaling module with TOR and PDK1-like kinases. Matsuo T, et al. EMBO J, 2003 Jun 16. PMID 12805221, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
      Title: TOR Complex 2- independent mutations in the regulatory PIF pocket of Gad8AKT1/SGK1 define separate branches of the stress response mechanisms in fission yeast.
    2. Here, the authors define a novel regulatory mechanism by which the motor activity and function of the fission yeast type one myosin, Myo1, is modulated by TORC2-signalling-dependent phosphorylation via Gad8.
      Title: TORC2-Gad8-dependent myosin phosphorylation modulates regulation by calcium.
    3. The Gad8 kinase (AKT homologue) phosphorylates fission yeast Tor1 at threonine (T1972) to reduce activity.
      Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
    4. Increased PKC(Pck2) expression prevented Gad8-TORC2 binding and so reduced the TORC2-mediated phosphorylation of Gad8 serine 546 that activates Gad8.
      Title: Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2.
    5. findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
      Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
    6. Gad8 positively regulates expression of cyclin-dependent kinase inhibitor gene rum1+, which is essential for cell cycle arrest.
      Title: Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of TORC2 signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase (AGC family) Gad8

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      912500..915238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023001.3 → NP_588010.1  serine/threonine protein kinase (AGC family) Gad8 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588010.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9P7J8
      Conserved Domains (3) summary
      PTZ00263
      Location:214 → 545
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd11651
      Location:66 → 225
      YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1
      cd05585
      Location:235 → 547
      STKc_YPK1_like; Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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