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    dcr1 dicer [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538930, updated on 18-Sep-2024

    Summary

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    Official Symbol
    dcr1
    Official Full Name
    dicer
    Primary source
    PomBase:SPCC188.13c
    Locus tag
    SPOM_SPCC188.13C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPCC584.10c
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    Genomic context

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    See dcr1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1504949..1510557, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prp19 complex subunit Prp45 Neighboring gene septin Spn6 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ER to Golgi ceramide transport protein, lipocalin superfamily Svf1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe. Gobeil LA, et al. Front Biosci, 2008 Jan 1. PMID 17981703, Free PMC Article
    2. An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer. Barraud P, et al. EMBO J, 2011 Aug 16. PMID 21847092, Free PMC Article
    3. Dicer is required for chromosome segregation and gene silencing in fission yeast cells. Provost P, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12482946, Free PMC Article
    4. Mediator directs co-transcriptional heterochromatin assembly by RNA interference-dependent and -independent pathways. Oya E, et al. PLoS Genet, 2013. PMID 23966866, Free PMC Article
    5. Bases of antisense lncRNA-associated regulation of gene expression in fission yeast. Wery M, et al. PLoS Genet, 2018 Jul. PMID 29975684, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Findings suggest that in S. pombe Dcr1 has a genome-wide role in terminating transcription by releasing Pol II at sites of collision between transcription and replication and thus maintains genome stability.
      Title: Dicer promotes transcription termination at sites of replication stress to maintain genome stability.
    2. Studies indicate that S. pombe genome encodes one of each of the core RNAi proteins, Dicer, Argonaute and RNA-dependent RNA polymerase (dcr1, ago1, rdp1).
      Title: RNAi mediates post-transcriptional repression of gene expression in fission yeast Schizosaccharomyces pombe.
    3. Data indicate that Argonaute, loaded with longer RNA precursors, recruits Triman (SPBC29A10.09c, 3'-5' Exonuclease) to generate dicer-independent priRNAs mature priRNAs and siRNAs.
      Title: Argonaute and Triman generate dicer-independent priRNAs and mature siRNAs to initiate heterochromatin formation.
    4. these results reveal novel insights into the mechanism of nuclear retention of Dcr1 and raise the possibility that this new class of dsRBDs might generally function in nucleocytoplasmic trafficking and not substrate binding
      Title: An extended dsRBD with a novel zinc-binding motif mediates nuclear retention of fission yeast Dicer.
    5. Dcr1 has a role in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe [review]
      Title: Involvement of Dcr1 in post-transcriptional regulation of gene expression in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables euchromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in co-transcriptional gene silencing by RNA interference machinery IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G0 to G1 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in siRNA-mediated pericentric heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in siRNA-mediated pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in termination of RNA polymerase I transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in termination of RNA polymerase III transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dicer

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1504949..1510557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023205.3 → NP_588215.2  dicer [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588215.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09884, Q9UUN1
      Conserved Domains (7) summary
      smart00535
      Location:912 → 1045
      RIBOc; Ribonuclease III family
      COG0571
      Location:1076 → 1345
      Rnc; dsRNA-specific ribonuclease [Transcription]
      COG1111
      Location:1 → 501
      MPH1; ERCC4-related helicase [Replication, recombination and repair]
      cd00046
      Location:26 → 188
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:1098 → 1247
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      pfam00271
      Location:343 → 464
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:538 → 620
      Dicer_dimer; Dicer dimerization domain
    Nucleotide Protein
    Heading Accession and Version

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