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    din1 RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542540, updated on 18-Sep-2024

    Summary

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    Official Symbol
    din1
    Official Full Name
    RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1
    Primary source
    PomBase:SPAC19D5.06c
    Locus tag
    SPOM_SPAC19D5.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rai1
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    Genomic context

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    See din1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5220220..5221494, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene U3 snoRNP-associated protein Imp3 Neighboring gene uncharacterized protein Neighboring gene DNA replication factor C complex subunit Ctf8 Neighboring gene mitophagy receptor Atg43 Neighboring gene 4-aminobutyrate aminotransferase (GABA transaminase) Neighboring gene ncRNA Neighboring gene Smc5-6 complex SMC P-loop ATPase subunit Smc5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32374864, Free PMC Article
    2. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Xiang S, et al. Nature, 2009 Apr 9. PMID 19194460, Free PMC Article
    3. The dhp1(+) gene, encoding a putative nuclear 5'-->3' exoribonuclease, is required for proper chromosome segregation in fission yeast. Shobuike T, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11238999, Free PMC Article
    4. 2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO. Picard-Jean F, et al. PLoS One, 2018. PMID 29601584, Free PMC Article
    5. A novel 5'-hydroxyl dinucleotide hydrolase activity for the DXO/Rai1 family of enzymes. Doamekpor SK, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31777937, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
      Title: DXO/Rai1 enzymes remove 5'-end FAD and dephospho-CoA caps on RNAs.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5'-hydroxyl dinucleotide hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA NAD+-cap (NAD+-forming) hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 5'-diphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA 5'-diphosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphodiesterase decapping endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in NAD-cap decapping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD-cap decapping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IC
    Inferred by Curator
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Las1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5220220..5221494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020334.3 → NP_594904.1  RNA NAD-cap (NAD-forming) hydrolase/RNA pyrophosphohydrolase Din1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594904.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13836
      Conserved Domains (1) summary
      pfam08652
      Location:200 → 283
      RAI1; RAI1 like PD-(D/E)XK nuclease
    Nucleotide Protein
    Heading Accession and Version

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