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    prp19 Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542256, updated on 18-Sep-2024

    Summary

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    Official Symbol
    prp19
    Official Full Name
    Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19
    Primary source
    PomBase:SPAC29A4.08c
    Locus tag
    SPOM_SPAC29A4.08C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    cwf8
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    Genomic context

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    See prp19 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (5133223..5135342)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene rRNA exonuclease Rrp17 Neighboring gene ncRNA Neighboring gene mediator complex subunit Med22 Neighboring gene splicing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene myosin I light chain Cam2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Prp19 WD40 domain contains a conserved protein interaction region essential for its function. Vander Kooi CW, et al. Structure, 2010 May 12. PMID 20462492, Free PMC Article
    2. Structural and functional analysis of essential pre-mRNA splicing factor Prp19p. Ohi MD, et al. Mol Cell Biol, 2005 Jan. PMID 15601865, Free PMC Article
    3. Identification of Nrl1 Domains Responsible for Interactions with RNA-Processing Factors and Regulation of Nrl1 Function by Phosphorylation. Mikolaskova B, et al. Int J Mol Sci, 2021 Jun 29. PMID 34209806, Free PMC Article
    4. Myb-related fission yeast cdc5p is a component of a 40S snRNP-containing complex and is essential for pre-mRNA splicing. McDonald WH, et al. Mol Cell Biol, 1999 Aug. PMID 10409726, Free PMC Article
    5. Interacting factors and cellular localization of SR protein-specific kinase Dsk1. Tang Z, et al. Exp Cell Res, 2012 Oct 1. PMID 22683458

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 1 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5133223..5135342
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020303.3 → NP_594874.1  Prp19 complex subunit, ubiquitin-protein ligase E4 Prp19 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594874.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14011
      Conserved Domains (4) summary
      sd00039
      Location:252 → 293
      7WD40; WD40 repeat [structural motif]
      cd16656
      Location:2 → 54
      RING-Ubox_PRP19; U-box domain, a modified RING finger, found in pre-mRNA-processing factor 19 (Prp19) and similar proteins
      pfam08606
      Location:67 → 131
      Prp19; Prp19/Pso4-like
      cl29593
      Location:237 → 434
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version

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