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    rum1 CDK inhibitor Rum1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539640, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rum1
    Official Full Name
    CDK inhibitor Rum1
    Primary source
    PomBase:SPBC32F12.09
    Locus tag
    SPOM_SPBC32F12.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rum1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2799677..2801917)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene DASH complex subunit Duo1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene phosphoglucomutase Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Requirement of PP2A-B56(Par1) for the Stabilization of the CDK Inhibitor Rum1 and Activation of APC/C(Ste9) during Pre-Start G1 in S. pombe. Stonyte V, et al. iScience, 2020 May 22. PMID 32361273, Free PMC Article
    2. Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1. Yu EY, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376070
    3. Interaction of cdc2 and rum1 regulates Start and S-phase in fission yeast. Labib K, et al. J Cell Sci, 1995 Oct. PMID 7593289
    4. Regulation of progression through the G1 phase of the cell cycle by the rum1+ gene. Moreno S, et al. Nature, 1994 Jan 20. PMID 8121488
    5. p25rum1 orders S phase and mitosis by acting as an inhibitor of the p34cdc2 mitotic kinase. Correa-Bordes J, et al. Cell, 1995 Dec 15. PMID 8521500

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic G1 cell size control checkpoint signaling EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mitotic G1 cell size control checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of mitotic DNA replication initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of mitotic cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    CDK inhibitor Rum1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2799677..2801917
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022071.3 → NP_596152.1  CDK inhibitor Rum1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596152.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74373, P40380
    Nucleotide Protein
    Heading Accession and Version

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