SET5 S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SET5
Official Full Name: S-adenosylmethionine-dependent methyltransferase
Primary source: SGD:S000001250
Locus tag: YHR207C
See related: AllianceGenome:SGD:S000001250; FungiDB:YHR207C; VEuPathDB:YHR207C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables S-adenosylmethionine-dependent methyltransferase activity. Involved in telomere maintenance. Located in chromatin. Orthologous to human SMYD5 (SMYD family member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SET5 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (514905..516485, complement)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that the MYND domain promotes Set5 chromatin association in cells and is required for its role in repressing subtelomeric genes.
Title: Function of the MYND Domain and C-Terminal Region in Regulating the Subcellular Localization and Catalytic Activity of the SMYD Family Lysine Methyltransferase Set5.
Set5 functions with Set1 to promote gene repression at telomeres.
Title: The histone methyltransferases Set5 and Set1 have overlapping functions in gene silencing and telomere maintenance.
Results revealed the novel functions of SET5 and PPR1 for the improvement of yeast acetic acid tolerance, and also implicated them in oxidative stress defense and energy metabolism in Saccharomyces cerevisiae.
Title: Improved growth and ethanol fermentation of Saccharomyces cerevisiae in the presence of acetic acid by overexpression of SET5 and PPR1.
The study uncovers novel pathways in which the methyltransferase Set5 participates and, more importantly, reveals a partnership between Set1 and Set5 in transcriptional repression near repetitive DNA elements in budding yeast.
Title: Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons.
Genetic studies revealed that Set5 functions in cellular processes that also rely on the global chromatin modifying complexes COMPASS and NuA4, which methylate H3 lysine 4 and acetylate H4 lysines 5, 8 and 12, respectively.
Title: New marks on the block: Set5 methylates H4 lysines 5, 8 and 12.
identify Set5 as the first histone H4 methyltransferase, which monomethylates the critical H4 lysine residues 5, 8 and 12 in budding yeast
Title: Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info
involved_in telomere maintenance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-adenosylmethionine-dependent methyltransferase

NP_012077.1

Methyltransferase involved in methylation of histone H4 Lys5, -8, -12; S-adenosylmethionine-dependent; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

514905..516485 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179338.1 → NP_012077.1 TPA: S-adenosylmethionine-dependent methyltransferase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012077.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZTB4, D3DLF6, P38890

UniProtKB/TrEMBL

B3LSW8, B5VKD6, C7GN92, C8ZA08, N1P324

Conserved Domains (1) summary

COG2940
Location:41 → 526

SET; SET domain-containing protein (function unknown) [General function prediction only]