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    gsk3 serine/threonine protein kinase Gsk3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542652, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gsk3
    Official Full Name
    serine/threonine protein kinase Gsk3
    Primary source
    PomBase:SPAC1687.15
    Locus tag
    SPOM_SPAC1687.15
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    skp1
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    Genomic context

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    See gsk3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (929831..932197)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene calcium-binding protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-5 sterol desaturase Erg31 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3. Wang T, et al. Life Sci Alliance, 2022 May. PMID 35121625, Free PMC Article
    2. Schizosaccharomyces pombe skp1+ encodes a protein kinase related to mammalian glycogen synthase kinase 3 and complements a cdc14 cytokinesis mutant. Plyte SE, et al. Mol Cell Biol, 1996 Jan. PMID 8524294, Free PMC Article
    3. Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe. Qingyun, et al. Kobe J Med Sci, 2016 Aug 3. PMID 27604537, Free PMC Article
    4. AMPKα Subunit Ssp2 and Glycogen Synthase Kinases Gsk3/Gsk31 are involved in regulation of sterol regulatory element-binding protein (SREBP) activity in fission yeast. Miao H, et al. PLoS One, 2020. PMID 32053662, Free PMC Article
    5. The role of Ppe1/PP6 phosphatase for equal chromosome segregation in fission yeast kinetochore. Goshima G, et al. EMBO J, 2003 Jun 2. PMID 12773390, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
      Title: Environmental control of Pub1 (NEDD4 family E3 ligase) in Schizosaccharomyces pombe is regulated by TORC2 and Gsk3.
    2. Data indicate that AMP-activated protein kinase beta subunit Amk2 (Amk2) and glycogen synthase kinase 3 (Gsk3) act in parallel to inhibit TORC1 (Tor2) function.
      Title: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes.
    3. Overexpression of the gsk3+ gene or the gsk31+ gene, another GSK3 member, rescues defective growth of Deltassp2 cells at restrictive temperatures and under glucose depletion as well as sexual differentiation under nitrogen depletion.
      Title: Genetic Interactions among AMPK Catalytic Subunit Ssp2 and Glycogen Synthase Kinases Gsk3 and Gsk31 in Schizosaccharomyces Pombe.
    4. Skp1 plays role in the checkpoint-signalling cascade.
      Title: Molecular interactions of fission yeast Skp1 and its role in the DNA damage checkpoint.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SREBP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of kinetochore assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase Gsk3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      929831..932197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018530.3 → NP_593134.1  serine/threonine protein kinase Gsk3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593134.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94456, Q10452
      Conserved Domains (2) summary
      smart00220
      Location:32 → 316
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14137
      Location:28 → 319
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    Nucleotide Protein
    Heading Accession and Version

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