U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    SUT1 Sut1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852714, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    SUT1
    Official Full Name
    Sut1p
    Primary source
    SGD:S000003130
    Locus tag
    YGL162W
    See related
    AllianceGenome:SGD:S000003130; FungiDB:YGL162W; VEuPathDB:YGL162W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including positive regulation of induction of conjugation with cellular fusion; positive regulation of sterol import; and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See SUT1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (198138..199037)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Yrb30p Neighboring gene DNA-dependent ATPase RAD54 Neighboring gene Yip5p Neighboring gene putative metalloreductase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Isolation and characterization of the Saccharomyces cerevisiae SUT1 gene involved in sterol uptake. Bourot S, et al. Gene, 1995 Nov 7. PMID 7489925
    2. SUT1 is a putative Zn[II]2Cys6-transcription factor whose upregulation enhances both sterol uptake and synthesis in aerobically growing Saccharomyces cerevisiae cells. Ness F, et al. Eur J Biochem, 2001 Mar. PMID 11248676
    3. SUT1 suppresses sec14-1 through upregulation of CSR1 in Saccharomyces cerevisiae. Régnacq M, et al. FEMS Microbiol Lett, 2002 Nov 5. PMID 12435498
    4. Predictive models of eukaryotic transcriptional regulation reveals changes in transcription factor roles and promoter usage between metabolic conditions. Holland P, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30976803, Free PMC Article
    5. SUT1-promoted sterol uptake involves the ABC transporter Aus1 and the mannoprotein Dan1 whose synergistic action is sufficient for this process. Alimardani P, et al. Biochem J, 2004 Jul 1. PMID 15035656, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of filamentous growth of a population of unicellular organisms IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of induction of conjugation with cellular fusion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of sterol import IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Sut1p
    NP_011353.1
    • Zn(II)2Cys6 family transcription factor; positively regulates sterol uptake genes under anaerobic conditions; involved in hypoxic gene expression; represses filamentation-inducing genes during vegetative growth; positively regulates mating with SUT2 by repressing expression of genes that act as mating inhibitors; repressed by STE12; relocalizes from the nucleus to the cytoplasm upon DNA replication stress; SUT1 has a paralog, SUT2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      198138..199037
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181027.1 → NP_011353.1  TPA: Sut1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011353.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTY9, P53032
      UniProtKB/TrEMBL
      C7GPP4, C8Z889, G2WDU2, N1PA08
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53032.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools