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    rad16 DNA repair endonuclease XPF [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538760, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rad16
    Official Full Name
    DNA repair endonuclease XPF
    Primary source
    PomBase:SPCC970.01
    Locus tag
    SPOM_SPCC970.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    rad10; rad20; swi9
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    Genomic context

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    See rad16 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    9
    Sequence:
    Chromosome: III; NC_003421.2 (514796..518097, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene cytochrome b5 reductase Neighboring gene ncRNA Neighboring gene mannan endo-1,6-alpha-mannosidase Neighboring gene ncRNA Neighboring gene kinetochore protein Mis18 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Prp11 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The rad16 gene of Schizosaccharomyces pombe: a homolog of the RAD1 gene of Saccharomyces cerevisiae. Carr AM, et al. Mol Cell Biol, 1994 Mar. PMID 8114734, Free PMC Article
    2. The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe. Hegde V, et al. Mol Gen Genet, 1996 Jun 24. PMID 8709952
    3. A novel protein, Rsf1/Pxd1, is critical for the single-strand annealing pathway of double-strand break repair in Schizosaccharomyces pombe. Wang H, et al. Mol Microbiol, 2015 Jun. PMID 25777942
    4. Some of the swi genes of Schizosaccharomyces pombe also have a function in the repair of radiation damage. Schmidt H, et al. Curr Genet, 1989 Aug. PMID 2598273
    5. Genetic control of radiation sensitivity in Schizosaccharomyces pombe. Nasim A, et al. Genetics, 1975 Apr. PMID 166019, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation.
      Title: CRL4Cdt2 ubiquitin ligase regulates Dna2 and Rad16 (XPF) nucleases by targeting Pxd1 for degradation.
    2. Schizosaccharomyces pombe Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.
      Title: Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 3' overhang single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via single-strand annealing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via single-strand annealing, removal of nonhomologous ends IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in gene conversion at mating-type locus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mating type switching IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitotic spindle pole body HDA PubMed 
    part_of nucleotide-excision repair factor 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleotide-excision repair factor 1 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    DNA repair endonuclease XPF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      514796..518097 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022848.3 → NP_587855.2  DNA repair endonuclease XPF [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587855.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P36617
      Conserved Domains (2) summary
      TIGR00596
      Location:90 → 875
      rad1; DNA repair protein (rad1)
      pfam02732
      Location:655 → 775
      ERCC4; ERCC4 domain
    Nucleotide Protein
    Heading Accession and Version

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