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    scs22 VAMP/synaptobrevin-associated protein family protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542179, updated on 14-Nov-2024

    Summary

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    Official Symbol
    scs22
    Official Full Name
    VAMP/synaptobrevin-associated protein family protein
    Primary source
    PomBase:SPAC17C9.12
    Locus tag
    SPOM_SPAC17C9.12
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See scs22 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (4477935..4479951, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene protein dhm2 Neighboring gene ncRNA Neighboring gene protein Pex19 Neighboring gene nuclear proteasome tethering factor Cut8 Neighboring gene ncRNA Neighboring gene zf-C2H2 type zinc finger protein/UBA domain protein Neighboring gene G-protein-coupled receptor Stm1 Neighboring gene TIM22 inner membrane protein import complex subunit Tim13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly. Zhang D, et al. Curr Biol, 2016 Mar 7. PMID 26877082, Free PMC Article
    2. A UPR-Induced Soluble ER-Phagy Receptor Acts with VAPs to Confer ER Stress Resistance. Zhao D, et al. Mol Cell, 2020 Sep 17. PMID 32735772
    3. ER-PM Contacts Restrict Exocytic Sites for Polarized Morphogenesis. Ng AYE, et al. Curr Biol, 2018 Jan 8. PMID 29290560
    4. Plasma membrane tethering of the cortical ER necessitates its finely reticulated architecture. Zhang D, et al. Curr Biol, 2012 Nov 6. PMID 23041194
    5. Fission yeast Duc1 links to ER-PM contact sites and influences PM lipid composition and cytokinetic ring anchoring. Willet AH, et al. J Cell Sci, 2024 Sep 15. PMID 39239853, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables endoplasmic reticulum-autophagosome adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables endoplasmic reticulum-plasma membrane adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum-plasma membrane tethering IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of ER location IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plasma membrane organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reticulophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT is_active_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cortical endoplasmic reticulum EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    VAMP/synaptobrevin-associated protein family protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4477935..4479951 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020022.3 → NP_594594.1  VAMP/synaptobrevin-associated protein family protein [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594594.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q10484
      Conserved Domains (2) summary
      COG5066
      Location:1 → 246
      SCS2; VAMP-associated protein involved in inositol metabolism [Intracellular trafficking and secretion]
      pfam00635
      Location:7 → 108
      Motile_Sperm; MSP (Major sperm protein) domain
    Nucleotide Protein
    Heading Accession and Version

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