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    doa10 ubiquitin ligase Doa10 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539855, updated on 18-Sep-2024

    Summary

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    Official Symbol
    doa10
    Official Full Name
    ubiquitin ligase Doa10
    Primary source
    PomBase:SPBC14F5.07
    Locus tag
    SPOM_SPBC14F5.07
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ssm4
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    Genomic context

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    See doa10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (4167479..4171911)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Fe-sulfur ATPase Rli1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mediator complex subunit Med7 Neighboring gene adenylosuccinate lyase Ade8 Neighboring gene ubiquitin-protein ligase E3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A ubiquitin-proteasome pathway degrades the inner nuclear membrane protein Bqt4 to maintain nuclear membrane homeostasis. Le TK, et al. J Cell Sci, 2023 Oct 1. PMID 37694715
    2. DNA binding by the MATα2 transcription factor controls its access to alternative ubiquitin-modification pathways. Hickey CM, et al. Mol Biol Cell, 2018 Mar 1. PMID 29298839, Free PMC Article
    3. Nuclear protein quality is regulated by the ubiquitin-proteasome system through the activity of Ubc4 and San1 in fission yeast. Matsuo Y, et al. J Biol Chem, 2011 Apr 15. PMID 21324894, Free PMC Article
    4. Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species. Beltrao P, et al. PLoS Biol, 2009 Jun 16. PMID 19547744, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inner nuclear membrane-associated protein degradation pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear inner membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin ligase Doa10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      4167479..4171911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022659.3 → NP_596733.1  ubiquitin ligase Doa10 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596733.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60103
      Conserved Domains (2) summary
      smart00744
      Location:7 → 55
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins
      COG5183
      Location:1 → 1239
      SSM4; E3 ubiquitin-protein ligase DOA10 [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version

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