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    hem1 5-aminolevulinate synthase [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542028, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hem1
    Official Full Name
    5-aminolevulinate synthase
    Primary source
    PomBase:SPAC2F3.09
    Locus tag
    SPOM_SPAC2F3.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hem1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3939665..3942086)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ribonuclease kappa-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GARP complex subunit Vps54

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shu1 is a cell-surface protein involved in iron acquisition from heme in Schizosaccharomyces pombe. Mourer T, et al. J Biol Chem, 2015 Apr 17. PMID 25733668, Free PMC Article
    2. The SH3 domains of two PCH family members cooperate in assembly of the Schizosaccharomyces pombe contractile ring. Roberts-Galbraith RH, et al. J Cell Biol, 2009 Jan 12. PMID 19139265, Free PMC Article
    3. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
    4. Predicting the fission yeast protein interaction network. Pancaldi V, et al. G3 (Bethesda), 2012 Apr. PMID 22540037, Free PMC Article
    5. Chromatin remodeller Fun30(Fft3) induces nucleosome disassembly to facilitate RNA polymerase II elongation. Lee J, et al. Nat Commun, 2017 Feb 20. PMID 28218250, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 5-aminolevulinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-aminolevulinate synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables pyridoxal phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transaminase activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5-aminolevulinate synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3939665..3942086
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019809.3 → NP_594388.1  5-aminolevulinate synthase [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594388.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O14092
      Conserved Domains (3) summary
      COG0156
      Location:132 → 525
      BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
      PRK09064
      Location:133 → 532
      PRK09064; 5-aminolevulinate synthase; Validated
      pfam09029
      Location:11 → 53
      Preseq_ALAS; 5-aminolevulinate synthase presequence
    Nucleotide Protein
    Heading Accession and Version

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